EFFECT OF NANO-TITANA IN RADIOTHERAPY: AN IN VIVO ANIMAL STUDY

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MASUMI HAMED; HASANZADEH HADI; REZAEI TAVIRANI MOSTAFA; JADIDI MAJID; NIKOUFAR ALIREZA; NASR REZA; DARBANDI AZAR AMIR; BITARAFAN RAJABI AHMAD; SEMNANI VAHID

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Journal: Journal of Mazandaran University of Medical Sciences Year:2017 | Volume:27 | Issue:149 Page(s): 1-13

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Title

EFFECT OF NANO-TITANA IN RADIOTHERAPY: AN IN VIVO ANIMAL STUDY

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Keywords

CANCERQ2

RADIOTHERAPYQ2

RADIATION SENSITIZERQ1

TIO2 NANOPARTICLEQ1

Abstract

Background and purpose: Among different CANCERs, breast CANCER has a high prevalence among women and RADIOTHERAPY is used as a treatment modality in which radio sensitizers are used to increase its efficiency. Nanoparticles are such sensitizers that enhance the efficiency of RADIOTHERAPY via creation of free radicals and induction of oxidative stress. This study aimed at evaluating the synergistic effect of radiation therapy and TiO2 nanoparticles on animal models of breast CANCER. Materials and methods: After induction of breast adenocarcinoma tumors in Balb/C, the animals were divided into several groups as control, rutile and anatase injections at 5mg/kg and 10mg/kg doses/with and without RADIOTHERAPY. Then, the efficiency of treatment was evaluated. Results: In groups receiving anatase nanoparticles with and without radiation, the values for tumor volume, relative volume and relative volume percentage showed a small increase and a considerable reduction, respectively. In rutile groups with and without radiation, these values showed a small increase and a considerable increase, respectively. IR value reduced to negative value and then increased to zero and positive in anatase groups with and without radiation. This parameter had little changes in rutile groups with and without radiation. Conclusion: Titanium dioxide nanoparticles increased sensitivity of tumor cells to radiation therapy due to ROS production. Compared with rutile crystals, anatase crystals have intense effect because of having a larger surface area and higher photocatalytic activity.

Cites

Effects of Combination Treatment of Cisplatin and Titanium Dioxide Nanoparticles on the BCL2L12 Gene in Prostate Cancer Cells

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APA: Copy

MASUMI, HAMED, HASANZADEH, HADI, REZAEI TAVIRANI, MOSTAFA, JADIDI, MAJID, NIKOUFAR, ALIREZA, NASR, REZA, DARBANDI AZAR, AMIR, BITARAFAN RAJABI, AHMAD, & SEMNANI, VAHID. (2017). EFFECT OF NANO-TITANA IN RADIOTHERAPY: AN IN VIVO ANIMAL STUDY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 27(149), 1-13. SID. https://sid.ir/paper/45453/en

Vancouver: Copy

MASUMI HAMED, HASANZADEH HADI, REZAEI TAVIRANI MOSTAFA, JADIDI MAJID, NIKOUFAR ALIREZA, NASR REZA, DARBANDI AZAR AMIR, BITARAFAN RAJABI AHMAD, SEMNANI VAHID. EFFECT OF NANO-TITANA IN RADIOTHERAPY: AN IN VIVO ANIMAL STUDY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;27(149):1-13. Available from: https://sid.ir/paper/45453/en

IEEE: Copy

HAMED MASUMI, HADI HASANZADEH, MOSTAFA REZAEI TAVIRANI, MAJID JADIDI, ALIREZA NIKOUFAR, REZA NASR, AMIR DARBANDI AZAR, AHMAD BITARAFAN RAJABI, and VAHID SEMNANI, “EFFECT OF NANO-TITANA IN RADIOTHERAPY: AN IN VIVO ANIMAL STUDY,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 149, pp. 1–13, 2017, [Online]. Available: https://sid.ir/paper/45453/en

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