CELLULAR EFFECTS OF NARINGIN IN PREVENTION OF GENOTOXICITY CAUSED BY MIFEPRISTONE ON HUMAN BLOOD LYMPHOCYTES

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SHOKRZADEH MOHAMMAD; RAHMATI KUKANDEH MAHBOUBE; KARGAR DARABI NARGES; MODANLOO MONA; FALLAH MARJAN; MOHAMMADPOUR ABASS

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:28 | Issue:161 Page(s): 115-120

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Title

CELLULAR EFFECTS OF NARINGIN IN PREVENTION OF GENOTOXICITY CAUSED BY MIFEPRISTONE ON HUMAN BLOOD LYMPHOCYTES

Author(s)

Keywords

MIFEPRISTONEQ1

NARINGINQ1

GENOTOXICITYQ1

MICRONUCLEUSQ2

Abstract

Background and purpose: MIFEPRISTONE is an oral synthetic steroid with antiglucocorticoidand antiprogesterone activities. Therefore, it could be dangerous during pregnancy since it causescytogenetic damage and, consequently, abortion. Flavonoid compounds such as NARINGIN have antioxidantproperties and eliminate various free radicals. NARINGIN is abundantly found in Iran, so, we investigated itscellular effects against cytogenetic damage caused by MIFEPRISTONE on blood lymphocyte usingmicronucleus method. Materials and Methods: In this experimental study, 5ml Venous blood were collected from 5healthy and non-smokers using heparin syringe. Different NARINGIN concentrations followed by 43μ g/mldamage dose of MIFEPRISTONE were injected to the cells. To evaluate the production of MICRONUCLEUS inrestrained binucleated lymphocytes in cytokine, the slides were prepared and evaluated by opticalmicroscopy. The mean values were compared applying ANOVA test (posttest: Tukey) in SPSS andp<0. 05 was regarded significant. Results: The highest frequency of MICRONUCLEUS was observed in the positive control group(17. 67± 1. 528) and the lowest was seen in the NARINGIN group at 232μ g/ml (1. 33+0. 5774) (P<0. 05). NARINGIN (232μ g/ml) with MIFEPRISTONE led to significant changes in the number of MICRONUCLEUS nucleicompared to the sample without NARINGIN. Conclusion: NARINGIN is a potent antigenotoxin against the damage caused by MIFEPRISTONEthan, therefore, it could be used as a protective agent against the toxic effects of MIFEPRISTONE.

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APA: Copy

SHOKRZADEH, MOHAMMAD, RAHMATI KUKANDEH, MAHBOUBE, KARGAR DARABI, NARGES, MODANLOO, MONA, FALLAH, MARJAN, & MOHAMMADPOUR, ABASS. (2018). CELLULAR EFFECTS OF NARINGIN IN PREVENTION OF GENOTOXICITY CAUSED BY MIFEPRISTONE ON HUMAN BLOOD LYMPHOCYTES. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(161 ), 115-120. SID. https://sid.ir/paper/45468/en

Vancouver: Copy

SHOKRZADEH MOHAMMAD, RAHMATI KUKANDEH MAHBOUBE, KARGAR DARABI NARGES, MODANLOO MONA, FALLAH MARJAN, MOHAMMADPOUR ABASS. CELLULAR EFFECTS OF NARINGIN IN PREVENTION OF GENOTOXICITY CAUSED BY MIFEPRISTONE ON HUMAN BLOOD LYMPHOCYTES. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;28(161 ):115-120. Available from: https://sid.ir/paper/45468/en

IEEE: Copy

MOHAMMAD SHOKRZADEH, MAHBOUBE RAHMATI KUKANDEH, NARGES KARGAR DARABI, MONA MODANLOO, MARJAN FALLAH, and ABASS MOHAMMADPOUR, “CELLULAR EFFECTS OF NARINGIN IN PREVENTION OF GENOTOXICITY CAUSED BY MIFEPRISTONE ON HUMAN BLOOD LYMPHOCYTES,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 161 , pp. 115–120, 2018, [Online]. Available: https://sid.ir/paper/45468/en

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