EFFECT OF CARBENOXOLONE ON INFLAMMATORY CYTOKINE LEVELS, FASTING BLOOD SUGAR, AND HISTOPATHOLOGY OF PANCREAS ONEXPERIMENTAL AUTOIMMUNE DIABETES IN C57BL/6 MICE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

RASOULI MEHDI; Jafari khataylou Yaser; ASHRAFI HELAN JAVAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:28 | Issue:161 Page(s): 1-11

Download Full-Text

Persian Verion

View:

593

Download:

Cites:

Information Journal Paper

Title

EFFECT OF CARBENOXOLONE ON INFLAMMATORY CYTOKINE LEVELS, FASTING BLOOD SUGAR, AND HISTOPATHOLOGY OF PANCREAS ONEXPERIMENTAL AUTOIMMUNE DIABETES IN C57BL/6 MICE

Author(s)

RASOULI MEHDI | Jafari khataylou Yaser | ASHRAFI HELAN JAVAD | Issue Writer Certificate

Keywords

TYPE 1 DIABETESQ2

CARBENOXOLONEQ2

PRE-INFLAMMATORY CYTOKINESQ1

HISTOPATHOLOGY OF PANCREASQ1

Abstract

Background and purpose: Destruction of insulin-producing beta cells by T cells causes type-1diabetes (T1D). CARBENOXOLONE has cytoprotective and anti-inflammatory effects, and has been shown tobe capable of suppressing Th17 cells that are effectively involved in the pathogenesis of TYPE 1 DIABETES, therefore, we studied the effect of CARBENOXOLONE on T1D in C57BL/6 mice. Materials and methods: Forty male C57BL/6 inbred strain mice were randomly divided intofour groups and in three groups diabetes was induced by streptozotocin. A positive control group wasconsidered and two other groups received 50 mg/kg/day i. p. CARBENOXOLONE (7 and 5 doses). Then, ondays 7 and 14 after the disease induction, fasting blood sugar (FBS) level, anti-inflammatory cytokinesIL-1β , IL-6 and TNF-α , and pathological changes of the pancreas were studied during the course of thedisease. Results: CARBENOXOLONE increased the levels of IL-1β , IL-6, TNF-α , and FBS. Also, itsignificantly increased infiltration of inflammatory cells into the pancreatic islets (P <0. 05). Conclusion: It seems that CARBENOXOLONE triggers a breakdown in Treg/Th17 balance byincreasing the levels of pro-inflammatory cytokines and increases the number of Th17 cells, therebycausing toxic effects on the pancreatic beta cells and increasing the severity of the disease.

Cites

No record.

References

No record.

Cite

APA: Copy

RASOULI, MEHDI, Jafari khataylou, Yaser, & ASHRAFI HELAN, JAVAD. (2018). EFFECT OF CARBENOXOLONE ON INFLAMMATORY CYTOKINE LEVELS, FASTING BLOOD SUGAR, AND HISTOPATHOLOGY OF PANCREAS ONEXPERIMENTAL AUTOIMMUNE DIABETES IN C57BL/6 MICE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(161 ), 1-11. SID. https://sid.ir/paper/45472/en

Vancouver: Copy

RASOULI MEHDI, Jafari khataylou Yaser, ASHRAFI HELAN JAVAD. EFFECT OF CARBENOXOLONE ON INFLAMMATORY CYTOKINE LEVELS, FASTING BLOOD SUGAR, AND HISTOPATHOLOGY OF PANCREAS ONEXPERIMENTAL AUTOIMMUNE DIABETES IN C57BL/6 MICE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;28(161 ):1-11. Available from: https://sid.ir/paper/45472/en

IEEE: Copy

MEHDI RASOULI, Yaser Jafari khataylou, and JAVAD ASHRAFI HELAN, “EFFECT OF CARBENOXOLONE ON INFLAMMATORY CYTOKINE LEVELS, FASTING BLOOD SUGAR, AND HISTOPATHOLOGY OF PANCREAS ONEXPERIMENTAL AUTOIMMUNE DIABETES IN C57BL/6 MICE,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 161 , pp. 1–11, 2018, [Online]. Available: https://sid.ir/paper/45472/en

Related Journal Papers