EXPRESSION OF ONCOPROTEIN GANKYRIN IN DRUG RESISTANT AND SENSITIVE CANCER OVARIAN AND GASTRIC CANCER CELL LINES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

TAHERI MARYAM; Jamialahmadi Khadijeh; KALALINIA FATEMEH

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:28 | Issue:161 Page(s): 12-23

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

576

Download:

Cites:

Information Journal Paper

Title

EXPRESSION OF ONCOPROTEIN GANKYRIN IN DRUG RESISTANT AND SENSITIVE CANCER OVARIAN AND GASTRIC CANCER CELL LINES

Author(s)

TAHERI MARYAM | Jamialahmadi Khadijeh | KALALINIA FATEMEH | Issue Writer Certificate

Keywords

GANKYRINQ1

MULTIDRUG RESISTANCEQ2

OVARIAN CANCERQ2

GASTRIC CANCERQ2

Abstract

Background and purpose: MULTIDRUG RESISTANCE (MDR) phenotype is a major complication incancer chemotherapy. GANKYRIN is a key point molecule in cell cycle regulation and may contribute todrug-resistance phenotype of tumor cells. The aim of this study was to compare the basal GANKYRINexpression level in ovarian and gastric drug-resistant cells with their parental drug-sensitive cells. Materials and methods: In this experimental study, the GANKYRIN expression at mRNA andprotein levels in drug resistance cell lines was compared with their parental drug sensitive cell lines byreal time RT-PCR and Western blotting. Results: GANKYRIN mRNA expression in A2780/RCIS cells was statistically lower than A2780cells (p= 0. 00) but their difference was not statistically significant at protein level (p= 0. 240). In addition, GANKYRIN expression in EPG85-257/RDB was lower than its parental drug sensitive cell line at mRNAand protein level. Conclusion: This study found an opposite relationship between GANKYRIN expression and MDRphenotype related to the overexpression of MDR transportes. This suggestes for the first time that theincidence of MDR phenotype could inhibit tumorgenisity.

Cites

No record.

References

No record.

Cite

APA: Copy

TAHERI, MARYAM, Jamialahmadi, Khadijeh, & KALALINIA, FATEMEH. (2018). EXPRESSION OF ONCOPROTEIN GANKYRIN IN DRUG RESISTANT AND SENSITIVE CANCER OVARIAN AND GASTRIC CANCER CELL LINES. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(161 ), 12-23. SID. https://sid.ir/paper/45479/en

Vancouver: Copy

TAHERI MARYAM, Jamialahmadi Khadijeh, KALALINIA FATEMEH. EXPRESSION OF ONCOPROTEIN GANKYRIN IN DRUG RESISTANT AND SENSITIVE CANCER OVARIAN AND GASTRIC CANCER CELL LINES. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;28(161 ):12-23. Available from: https://sid.ir/paper/45479/en

IEEE: Copy

MARYAM TAHERI, Khadijeh Jamialahmadi, and FATEMEH KALALINIA, “EXPRESSION OF ONCOPROTEIN GANKYRIN IN DRUG RESISTANT AND SENSITIVE CANCER OVARIAN AND GASTRIC CANCER CELL LINES,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 161 , pp. 12–23, 2018, [Online]. Available: https://sid.ir/paper/45479/en

Related Journal Papers