Association between MTHFR Gene Polymorphism (C677T) and Coronary Artery Disease

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Golchin Soheyla; HEDAYATIZADEH OMRAN AKBAR; ALIZADEH NAVAEI REZA; MOKHBERI VAHID; OMRANI NAVA VERSA; AMJADI OMOLBANIN; Mahmoud babouei Mohammad

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2019 | Volume:28 | Issue:168 Page(s): 50-58

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Title

Association between MTHFR Gene Polymorphism (C677T) and Coronary Artery Disease

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Keywords

MTHFR polymorphismQ1

Coronary Artery DiseaseQ1

C677T VariantQ1

Abstract

Background and purpose: Coronary Artery Disease (CAD) is a complex disease that is caused by both environmental and genetic factors. Methylenetetrahydrofolate (MTHFR) enzyme is associated with metabolism of homocysteine and its impaired function is considered as a risk factor for developing CAD. Some variants are involved in decreased activity of MTHFR and its deficiency. The polymorphism of C677T (rs1801133) seems to be a significant variant that is related with CAD. The purpose of this study was to determine the relationship between MTHFR C677T gene polymorphism and susceptibility of CAD. Materials and methods This case-control study was performed in 71 patients with Coronary Artery Disease and 71 healthy subjects (control group). Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to genotype MTHFR polymorphism. Results The mean ages of subjects in case and control groups were 58. 2± 8. 9 and 46± 13. 9 years, respectively (P= 0. 0000). The case group included 37 (52. 1%) males and 34 (47. 9%) females. In control group, there were 38 (53. 5%) males and 33 (46. 5%) females. The frequency of CC, CT, and TT genotypes in C677T polymorphisms was 59. 2%, 35. 2%, and 5. 6%, in CAD patients and 62%, 32. 4%, and 5. 4%, in controls, respectively, indicating no significant differences between the cases and controls (p= 0. 937). The frequency of T allele was 40. 8% in cases and 38% in controls which also showed no significant difference between the two groups (P= 0. 864). Conclusion Current study found no relationship between MTHFR C677T gene polymorphism and CAD. However, further studies in larger population are recommended to achieve better understand this relationship.

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APA: Copy

Golchin, Soheyla, HEDAYATIZADEH OMRAN, AKBAR, ALIZADEH NAVAEI, REZA, MOKHBERI, VAHID, OMRANI NAVA, VERSA, AMJADI, OMOLBANIN, & Mahmoud babouei, Mohammad. (2019). Association between MTHFR Gene Polymorphism (C677T) and Coronary Artery Disease. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(168 ), 50-58. SID. https://sid.ir/paper/45593/en

Vancouver: Copy

Golchin Soheyla, HEDAYATIZADEH OMRAN AKBAR, ALIZADEH NAVAEI REZA, MOKHBERI VAHID, OMRANI NAVA VERSA, AMJADI OMOLBANIN, Mahmoud babouei Mohammad. Association between MTHFR Gene Polymorphism (C677T) and Coronary Artery Disease. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;28(168 ):50-58. Available from: https://sid.ir/paper/45593/en

IEEE: Copy

Soheyla Golchin, AKBAR HEDAYATIZADEH OMRAN, REZA ALIZADEH NAVAEI, VAHID MOKHBERI, VERSA OMRANI NAVA, OMOLBANIN AMJADI, and Mohammad Mahmoud babouei, “Association between MTHFR Gene Polymorphism (C677T) and Coronary Artery Disease,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 168 , pp. 50–58, 2019, [Online]. Available: https://sid.ir/paper/45593/en

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