BRIEF REPORT: EVALUATING THE CYTOTOXICITY EFFECT OF HYDROALCOHOLIC EXTRACT OF JUGLANS REGIA ON HUMAN CANCER CELL LINES (HEPG2- HELA) BY MTT ASSAY

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SHOKRZADEH MOHAMMAD; HABIBI EMRAN; DADKHAH GOLARA; MODANLOO MONA

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2016 | Volume:26 | Issue:141 Page(s): 160-164

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Title

BRIEF REPORT: EVALUATING THE CYTOTOXICITY EFFECT OF HYDROALCOHOLIC EXTRACT OF JUGLANS REGIA ON HUMAN CANCER CELL LINES (HEPG2- HELA) BY MTT ASSAY

Author(s)

SHOKRZADEH MOHAMMAD | HABIBI EMRAN | DADKHAH GOLARA | MODANLOO MONA | Issue Writer Certificate

Keywords

JUGLANS REGIAQ1

CANCER CELL LINESQ1

INHIBITORY CONCENTRATION 50Q1

MTT ASSAYQ2

Abstract

Background and purpose: Today medicinal plants have received much attention in treatment of many cancers.JUGLANS REGIA has phenolic compounds and is used in cytotoxicity studies. This study investigated the effects of hydroalcoholic extract of JUGLANS REGIA on the growth of human cervical and liver cancer cells.Materials and methods: The hydroalcoholic extract of the fruit of JUGLANS REGIA was prepared by percolation method. The HeLa and HepG2 cancer cells were cultivated and further incubated with different concentrations of the extract. After 72 hours, cell growth inhibition was examined using MTT ASSAY. The results were statistically analyzed in Prism ver.3 applying ANOVA and post-test.Results: The INHIBITORY CONCENTRATION 50 (IC50) of the plant extract on human HepG2 and HeLa cancer cells were 449.1 ± 18.26 mg/ml and 222.4 ± 2.66 mg/ml, respectively. The IC50of Cisplatin on these cancer cells were found to be 15.96±1.117and 15.79±1.147 mg/ml, respectively.Conclusion: The IC50of JUGLANS REGIA on HeLa and HepG2 was more than that in Cisplatin.Accordingly, further investigations are needed on other CANCER CELL LINES. Moreover, due to the fact that the extract was total, future studies should aim at identifying its active substances.

Cites

CYTOTOXIC EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF CROCUS CASPIUS ON BREAST CANER CELL LINES

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APA: Copy

SHOKRZADEH, MOHAMMAD, HABIBI, EMRAN, DADKHAH, GOLARA, & MODANLOO, MONA. (2016). BRIEF REPORT: EVALUATING THE CYTOTOXICITY EFFECT OF HYDROALCOHOLIC EXTRACT OF JUGLANS REGIA ON HUMAN CANCER CELL LINES (HEPG2- HELA) BY MTT ASSAY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 26(141), 160-164. SID. https://sid.ir/paper/45603/en

Vancouver: Copy

SHOKRZADEH MOHAMMAD, HABIBI EMRAN, DADKHAH GOLARA, MODANLOO MONA. BRIEF REPORT: EVALUATING THE CYTOTOXICITY EFFECT OF HYDROALCOHOLIC EXTRACT OF JUGLANS REGIA ON HUMAN CANCER CELL LINES (HEPG2- HELA) BY MTT ASSAY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;26(141):160-164. Available from: https://sid.ir/paper/45603/en

IEEE: Copy

MOHAMMAD SHOKRZADEH, EMRAN HABIBI, GOLARA DADKHAH, and MONA MODANLOO, “BRIEF REPORT: EVALUATING THE CYTOTOXICITY EFFECT OF HYDROALCOHOLIC EXTRACT OF JUGLANS REGIA ON HUMAN CANCER CELL LINES (HEPG2- HELA) BY MTT ASSAY,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 141, pp. 160–164, 2016, [Online]. Available: https://sid.ir/paper/45603/en

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