HISTOPATHOLOGIC EFFECTS OF FORMALDEHYDE EXPOSURE ON RAT KIDNEY

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DAVARIAN A.; HASHEMNEZHAD HANIF; AZARHOUSH R.; GOL ALIPOUR M.J.; FAZELI S.A.

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Title

HISTOPATHOLOGIC EFFECTS OF FORMALDEHYDE EXPOSURE ON RAT KIDNEY

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Keywords

FORMALDEHYDE EXPOSUREQ3

HISTOPATHOLOGIC CHANGESQ3

KIDNEYQ2

RATQ2

Abstract

Background and purpose: Formaldehyde is a chemical traditionally used for fixing the cadaver. It is vaporized during dissection and practical studying on cadaver. Studies show that this vapour can cause some clinical sympotms such as throat, eye, skin and nasal irritation.This study was designed to determine the histopathological changes of RAT KIDNEY tissue exposed to formaldehyde for 18 weeks.Materials and Methods: This study was perfonned on 28, 6-7 weeks postnatal albino Wistar RATs. The RATs were divided into 3 case groups (E1: 4hrs/d, 4d/w; E2: 2hrs/d, 4d/w; E3: 2hrs/d, 2d/w) and one control group (C). The KIDNEY specimens were sectioned and stained with H&E technique for histopathological study.Results: In all histopathology sections of groups E1, E2 and E3, the following similar changes were observed: Mild congestion in the glumeroles, focal congestion and vacuolar (hydropic) degeneration of tubular cells only mild non-specific congestion in renal vessels. There were no evidences of fibrotic change or inflammatory cells infiltration among interstitial tissue. Also there were no abnonnalities in the staining of nucleus and cytoplasm. In Control group (C), no HISTOPATHOLOGIC CHANGES were observed.Conclusion: The results of this study showed that formaldehyde vapour with a concentrations used in our study, can not induce HISTOPATHOLOGIC CHANGES which could be detectable by light microscope.Also, there is no direct relationship between the duration of exposure to formaldehyde vapour and the intensity of HISTOPATHOLOGIC CHANGES in the KIDNEY.

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APA: Copy

DAVARIAN, A., HASHEMNEZHAD, HANIF, AZARHOUSH, R., GOL ALIPOUR, M.J., & FAZELI, S.A.. (2007). HISTOPATHOLOGIC EFFECTS OF FORMALDEHYDE EXPOSURE ON RAT KIDNEY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 16(56), 101-107. SID. https://sid.ir/paper/45630/en

Vancouver: Copy

DAVARIAN A., HASHEMNEZHAD HANIF, AZARHOUSH R., GOL ALIPOUR M.J., FAZELI S.A.. HISTOPATHOLOGIC EFFECTS OF FORMALDEHYDE EXPOSURE ON RAT KIDNEY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2007;16(56):101-107. Available from: https://sid.ir/paper/45630/en

IEEE: Copy

A. DAVARIAN, HANIF HASHEMNEZHAD, R. AZARHOUSH, M.J. GOL ALIPOUR, and S.A. FAZELI, “HISTOPATHOLOGIC EFFECTS OF FORMALDEHYDE EXPOSURE ON RAT KIDNEY,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 16, no. 56, pp. 101–107, 2007, [Online]. Available: https://sid.ir/paper/45630/en

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