EVALUATION OF NALTREXONE AUGMENTATION TO THE ANTIPSYCHOTIC DRUGS ON POSITIVE AND NEGATIVE SYMPTOMS OF SCHIZOPHRENIA

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SETAREH J.; HAJATI GH.R.; ZARGHAMI M.; ALA ALDINI F.; MIRZADEH S.M.M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2008 | Volume:18 | Issue:66 Page(s): 10-18

Download Full-Text

Persian Verion

View:

1,157

Download:

Cites:

Information Journal Paper

Title

EVALUATION OF NALTREXONE AUGMENTATION TO THE ANTIPSYCHOTIC DRUGS ON POSITIVE AND NEGATIVE SYMPTOMS OF SCHIZOPHRENIA

Author(s)

Keywords

ANTIPSYCHOTICQ2

SCHIZOPHRENIAQ3

OPIOIDQ3

NALTROXANEQ3

Abstract

Background and Purpose: In recent years, review of OPIOID system and its changes in the psychopathology of SCHIZOPHRENIA through thear probable role our on neuronal synopses and cell body of dopaminergic neurons and also decrease dopamine secretion from acumbans nuclei and effects of opium agonists in treatment of those patients has been adventajes for clinicians.Materials and methods: In a prospective double blind evaluation, 60 chronic schizophrenic inpatients on a stable regimen of neuroleptic medication with positive and negative symptom scale (PANSS) score of higher than 80 and were randomly assigned to either ANTIPSYCHOTIC plus naltrexone or ANTIPSYCHOTIC plus placebo. Thirty patients (30) received 100 mg/day of naltrexone plus ANTIPSYCHOTIC drug while 30 received placebo plus ANTIPSYCHOTIC drug for 6 weeks. PANSS scores were evaluated on the base of the study, biweekly throughout the study and two weeks after the trial. The treatment effect was calculated by repeated measurement ANOVA.Results: Difference between four types of symptoms (positive symptom, negative symptom, general psychopathological symptom, total score of PANSS) in the case and control groups was not significant (P<0.05). In supplement two (S2) scores, a statistically no significant difference was seen in two groups (P<0.07).Conclusion: Additional treatment with 100 mg/day naltrexone in a 6 week trial had no significant therapeutic effect on typical or atypical ANTIPSYCHOTIC drugs with regards to SCHIZOPHRENIA psychopathology.

Cites

No record.

References

No record.

Cite

APA: Copy

SETAREH, J., HAJATI, GH.R., ZARGHAMI, M., ALA ALDINI, F., & MIRZADEH, S.M.M.. (2008). EVALUATION OF NALTREXONE AUGMENTATION TO THE ANTIPSYCHOTIC DRUGS ON POSITIVE AND NEGATIVE SYMPTOMS OF SCHIZOPHRENIA. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 18(66), 10-18. SID. https://sid.ir/paper/45654/en

Vancouver: Copy

SETAREH J., HAJATI GH.R., ZARGHAMI M., ALA ALDINI F., MIRZADEH S.M.M.. EVALUATION OF NALTREXONE AUGMENTATION TO THE ANTIPSYCHOTIC DRUGS ON POSITIVE AND NEGATIVE SYMPTOMS OF SCHIZOPHRENIA. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2008;18(66):10-18. Available from: https://sid.ir/paper/45654/en

IEEE: Copy

J. SETAREH, GH.R. HAJATI, M. ZARGHAMI, F. ALA ALDINI, and S.M.M. MIRZADEH, “EVALUATION OF NALTREXONE AUGMENTATION TO THE ANTIPSYCHOTIC DRUGS ON POSITIVE AND NEGATIVE SYMPTOMS OF SCHIZOPHRENIA,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 18, no. 66, pp. 10–18, 2008, [Online]. Available: https://sid.ir/paper/45654/en

Related Journal Papers