PROTECTIVE EFFECTS OF HYDROALCOHOLIC EXTRACT OF NASTURTIUM OFFICINALE AGAINST GENTAMICIN INDUCED MITOCHONDRIAL DYSFUNCTION IN RAT KIDNEY

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SHAHANI SOMAYEH; BEHZADFAR FARZANEH; JAHANI DANIEL; SHAKI FATEMEH

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Journal: Journal of Mazandaran University of Medical Sciences Year:2017 | Volume:26 | Issue:145 Page(s): 152-164

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Title

PROTECTIVE EFFECTS OF HYDROALCOHOLIC EXTRACT OF NASTURTIUM OFFICINALE AGAINST GENTAMICIN INDUCED MITOCHONDRIAL DYSFUNCTION IN RAT KIDNEY

Author(s)

SHAHANI SOMAYEH | BEHZADFAR FARZANEH | JAHANI DANIEL | SHAKI FATEMEH | Issue Writer Certificate

Keywords

GENTAMICINQ3

NASTURTIUMQ2

MITOCHONDRIAQ2

NEPHROTOXICITYQ1

Abstract

Background and purpose: In this study, we evaluated the protective effects of hydroalcoholic extract of NASTURTIUM officinale (watercress) against GM-induced MITOCHONDRIAl dysfunction on isolated rat kidney MITOCHONDRIA.Materials and methods: In this study, 36 Wistar rats were divided into six groups (n=6 per group): control, solvent, GM (80 mg/kg IP), and GM and three doses (50, 100, 200 mg/kg/day, IP) of hydroalcoholic extract of aerial parts of watercress. After 10 consecutive days of injection, the animals were killed and kidney tissues were separated. Then, the MITOCHONDRIA were isolated using different centrifuge technique and the parameters of MITOCHONDRIAl damage were evaluated.Results: Administration of GM for 10 days resulted in decrease in MITOCHONDRIAl function in MTT test and also the glutathione content in kidney isolated MITOCHONDRIA. Compared with the control group, increase in lipid peroxidation and MITOCHONDRIAl swelling was observed in GM group. The NASTURTIUM officinale extract could significantly reduce (dose dependent) the increase in glutathione oxidation, lipid peroxidation and MITOCHONDRIAl swelling due to GM on kidney isolated MITOCHONDRIA.Conclusion: With the considering the protective effects of NASTURTIUM officinale in attenuating GM-induced MITOCHONDRIAl damage, it can be suggested for prevention of pathological condition caused by MITOCHONDRIAl damage.

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APA: Copy

SHAHANI, SOMAYEH, BEHZADFAR, FARZANEH, JAHANI, DANIEL, & SHAKI, FATEMEH. (2017). PROTECTIVE EFFECTS OF HYDROALCOHOLIC EXTRACT OF NASTURTIUM OFFICINALE AGAINST GENTAMICIN INDUCED MITOCHONDRIAL DYSFUNCTION IN RAT KIDNEY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 26(145), 152-164. SID. https://sid.ir/paper/45756/en

Vancouver: Copy

SHAHANI SOMAYEH, BEHZADFAR FARZANEH, JAHANI DANIEL, SHAKI FATEMEH. PROTECTIVE EFFECTS OF HYDROALCOHOLIC EXTRACT OF NASTURTIUM OFFICINALE AGAINST GENTAMICIN INDUCED MITOCHONDRIAL DYSFUNCTION IN RAT KIDNEY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;26(145):152-164. Available from: https://sid.ir/paper/45756/en

IEEE: Copy

SOMAYEH SHAHANI, FARZANEH BEHZADFAR, DANIEL JAHANI, and FATEMEH SHAKI, “PROTECTIVE EFFECTS OF HYDROALCOHOLIC EXTRACT OF NASTURTIUM OFFICINALE AGAINST GENTAMICIN INDUCED MITOCHONDRIAL DYSFUNCTION IN RAT KIDNEY,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 145, pp. 152–164, 2017, [Online]. Available: https://sid.ir/paper/45756/en

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