PHYLOGENETIC AND IN SILICO ANALYSIS OF INTERFERON BETA-1B PROTEIN

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MIRHOSEINI SEYEDZIAEDDIN; PEZESHKIAN ZAHRA; GHOVVATI SHAHROKH

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Journal: Journal of Mazandaran University of Medical Sciences Year:2017 | Volume:26 | Issue:145 Page(s): 70-82

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Title

PHYLOGENETIC AND IN SILICO ANALYSIS OF INTERFERON BETA-1B PROTEIN

Author(s)

MIRHOSEINI SEYEDZIAEDDIN | PEZESHKIAN ZAHRA | GHOVVATI SHAHROKH | Issue Writer Certificate

Keywords

INTERFERON BETA-1BQ1

BIOINFORMATICS TOOLSQ1

MULTIPLE SCLEROSISQ1

IN SILICO ANALYSISQ1

PROTEINPROTEIN INTERACTIONQ1

Abstract

Background and purpose: INTERFERON BETA-1B recombinant protein is used for reducing the relapse rate and treatment in patients with MULTIPLE SCLEROSIS (MS). In this study, phylogenetic and IN SILICO ANALYSIS of INTERFERON BETA-1B were conducted by servers and BIOINFORMATICS TOOLS to predict its structural potential.Materials and methods: Physiological and physico-chemical characteristics of interferon beta- 1b protein were evaluated by ProtScale and ProtParam servers, respectively. The 3D structure of the INTERFERON BETA-1B protein and its interaction with other proteins were studied using Swiss-Model server and the STRING platform, respectively.Results: The results of the phylogenetic analysis showed that the human interferon beta protein is closest to Daubenton's bat in the amino acid structure by 96%. The IN SILICO ANALYSIS of interferon beta 1b protein implied the existence of signal peptide and lack of the transmembrane domain. The results of post-translational modification predictions showed that protein acetylation and phosphorylation may occur in some regions of INTERFERON BETA-1B protein. The analysis of the protein networking of INTERFERON BETA-1B revealed more interactions between this protein and interferon receptor 1 (IFNAR1) and interferon regulatory factor 3 (IRF3).Conclusion: IN SILICO ANALYSIS showed that INTERFERON BETA-1B, is a protein with effective regulatory role but unstable in vitro. This bioinformatic analysis of INTERFERON BETA-1B protein can provide the groundwork for practical tests and future functional studies.

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APA: Copy

MIRHOSEINI, SEYEDZIAEDDIN, PEZESHKIAN, ZAHRA, & GHOVVATI, SHAHROKH. (2017). PHYLOGENETIC AND IN SILICO ANALYSIS OF INTERFERON BETA-1B PROTEIN. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 26(145), 70-82. SID. https://sid.ir/paper/45757/en

Vancouver: Copy

MIRHOSEINI SEYEDZIAEDDIN, PEZESHKIAN ZAHRA, GHOVVATI SHAHROKH. PHYLOGENETIC AND IN SILICO ANALYSIS OF INTERFERON BETA-1B PROTEIN. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;26(145):70-82. Available from: https://sid.ir/paper/45757/en

IEEE: Copy

SEYEDZIAEDDIN MIRHOSEINI, ZAHRA PEZESHKIAN, and SHAHROKH GHOVVATI, “PHYLOGENETIC AND IN SILICO ANALYSIS OF INTERFERON BETA-1B PROTEIN,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 145, pp. 70–82, 2017, [Online]. Available: https://sid.ir/paper/45757/en

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