EXPRESSION OF INTERLEUKIN 11 (IL-11) IN BENIGN AND MALIGNANT LESIONS OF THE GASTRIC MUCOSA

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GHORBANALIPOOR SAEEDEH; AJAMI ABOLGHASEM; RAFIEE ALIREZA; TAGHVAEI TORANG; PAYLAKHI SEYED HASAN; HOSSEINI VAHID

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Journal: Journal of Mazandaran University of Medical Sciences Year:2011 | Volume:21 | Issue:84 Page(s): 2-11

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Title

EXPRESSION OF INTERLEUKIN 11 (IL-11) IN BENIGN AND MALIGNANT LESIONS OF THE GASTRIC MUCOSA

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Keywords

IL-11Q2

BENIGN GASTRIC MUCOSAQ2

MALIGNANT GASTRIC MUCOSAQ2

Abstract

Background and purpose: Gastric cancer has been considered as the second lethal cancer throughout the world and the incidence of this cancer in Iran is 25 in 10000 people per year. Interleukin- 11 (IL-11), a member of IL-6 family, may play some role in developing gastric cancer via activation of the JAK/STAT signaling pathway. In this study, the level of IL-11 gene expression was determined in gastric biopsy specimens of patients with and without gastric cancer.Materials and methods: In this case-control study, biopsy specimens were collected from Imam Khomeini Hospital and Tooba Clinic in Sari. Based on the histopathologic and endoscopic assessments, patients were divided into two groups of gastric cancer patients (n=45) and those without gastric cancer (n=45). To determine the level of gene expression of IL-11, SYBR Green Real-time PCR method was employed. The obtained data were analyzed using REST 2008 and SPSS16.Results: The histopathology of the biopsy specimens were determined as intestinal adenocarcinoma (93.4%), diffused adenocarcinoma (4.4%), and carcinoid tumor (2.2%). The level of IL-11 gene expression was significantly higher in gastric cancer samples compared with individuals (p<0.05); moreover, no change in the expression of this gene in patients with other digestive complications without gastric cancer was observed (p=0.81).Conclusion: It is suggested that IL-11 has relationship with developing gastric cancer and it is likely involved in the process of tumorgenesis, proliferation and survival by increasing the anti-apoptotic activity.

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APA: Copy

GHORBANALIPOOR, SAEEDEH, AJAMI, ABOLGHASEM, RAFIEE, ALIREZA, TAGHVAEI, TORANG, PAYLAKHI, SEYED HASAN, & HOSSEINI, VAHID. (2011). EXPRESSION OF INTERLEUKIN 11 (IL-11) IN BENIGN AND MALIGNANT LESIONS OF THE GASTRIC MUCOSA. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 21(84), 2-11. SID. https://sid.ir/paper/45969/en

Vancouver: Copy

GHORBANALIPOOR SAEEDEH, AJAMI ABOLGHASEM, RAFIEE ALIREZA, TAGHVAEI TORANG, PAYLAKHI SEYED HASAN, HOSSEINI VAHID. EXPRESSION OF INTERLEUKIN 11 (IL-11) IN BENIGN AND MALIGNANT LESIONS OF THE GASTRIC MUCOSA. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2011;21(84):2-11. Available from: https://sid.ir/paper/45969/en

IEEE: Copy

SAEEDEH GHORBANALIPOOR, ABOLGHASEM AJAMI, ALIREZA RAFIEE, TORANG TAGHVAEI, SEYED HASAN PAYLAKHI, and VAHID HOSSEINI, “EXPRESSION OF INTERLEUKIN 11 (IL-11) IN BENIGN AND MALIGNANT LESIONS OF THE GASTRIC MUCOSA,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. 84, pp. 2–11, 2011, [Online]. Available: https://sid.ir/paper/45969/en

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