THE EFFECT OF TAMOXIFEN IN THE TREATMENT OF IDIOPATHIC GYNECOMASTIA: BRIEF REPORT

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NIKBAKHSH NOVIN; MOGHADDAMNIA ALIAKBAR; HASHEMI SEYED REZA; MAHMOUDI MOHSEN

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2011 | Volume:21 | Issue:84 Page(s): 139-143

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Title

THE EFFECT OF TAMOXIFEN IN THE TREATMENT OF IDIOPATHIC GYNECOMASTIA: BRIEF REPORT

Author(s)

NIKBAKHSH NOVIN | MOGHADDAMNIA ALIAKBAR | HASHEMI SEYED REZA | MAHMOUDI MOHSEN | Issue Writer Certificate

Keywords

TAMOXIFENQ2

GYNECOMASTIAQ3

BREAST TENDERNESSQ2

BREAST SIZEQ2

Abstract

Background and purpose: GYNECOMASTIA -benign proliferation of male breast glandular tissueoccurs due to increased ratio of estrogen to androgen activity. Considering the lack of studies on the effects of TAMOXIFEN on GYNECOMASTIA in Iran, and also scarcity of such studies in other countries, this study was conducted to determine the effect of TAMOXIFEN in the treatment of GYNECOMASTIA.Materials and methods: In this quasi-experimental study, patients with idiopathic GYNECOMASTIA, after obtaining consent, were treated with TAMOXIFEN (10-20 mg/day) for 6 months. At baseline and after starting treatment each month, criteria such as pain, tenderness and BREAST SIZE were investigated and recorded. Criteria of response to treatment were decreased BREAST SIZE and tenderness. The data analysis was done by Wilcoxon, Friedman, McNemar and Repeated measurements tests.Results: Thirty patients entered the study, at baseline 24 patients had tenderness, but in the third and also the sixth month of treatment this number decreased to 2 patients (p<0.05). In the third month, the mean decrease in BREAST SIZE compared to baseline was 12.869±9.79 mm (p<0.05) and in the sixth month 24.70±19.71 mm (p<0.05). The size also had a significant decrease during treatment (p<0.05).Conclusion: Based on the results of this study, TAMOXIFEN is an effective medication for GYNECOMASTIA and considering the amount of reduction in BREAST SIZE and tenderness, this medication is suggested for treatment of gynecoastia.

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APA: Copy

NIKBAKHSH, NOVIN, MOGHADDAMNIA, ALIAKBAR, HASHEMI, SEYED REZA, & MAHMOUDI, MOHSEN. (2011). THE EFFECT OF TAMOXIFEN IN THE TREATMENT OF IDIOPATHIC GYNECOMASTIA: BRIEF REPORT. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 21(84), 139-143. SID. https://sid.ir/paper/45974/en

Vancouver: Copy

NIKBAKHSH NOVIN, MOGHADDAMNIA ALIAKBAR, HASHEMI SEYED REZA, MAHMOUDI MOHSEN. THE EFFECT OF TAMOXIFEN IN THE TREATMENT OF IDIOPATHIC GYNECOMASTIA: BRIEF REPORT. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2011;21(84):139-143. Available from: https://sid.ir/paper/45974/en

IEEE: Copy

NOVIN NIKBAKHSH, ALIAKBAR MOGHADDAMNIA, SEYED REZA HASHEMI, and MOHSEN MAHMOUDI, “THE EFFECT OF TAMOXIFEN IN THE TREATMENT OF IDIOPATHIC GYNECOMASTIA: BRIEF REPORT,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. 84, pp. 139–143, 2011, [Online]. Available: https://sid.ir/paper/45974/en

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