EVALUATION OF ANTI-DIABETIC AND ANTI-NEUROPATHY PROPERTIES OF RESVERATROL AND ITS EFFECT ON SIRT-1 EXPRESSION IN MICE

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SAED AMIN; MOJTABAVI SOMAYYEH; NAJAFI MOJTABA; ZIAR ALI; HAGHI HAMED; ATAEE RAMIN

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:27 | Issue:157 Page(s): 59-69

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Title

EVALUATION OF ANTI-DIABETIC AND ANTI-NEUROPATHY PROPERTIES OF RESVERATROL AND ITS EFFECT ON SIRT-1 EXPRESSION IN MICE

Author(s)

Keywords

RESVERATROLQ1

ANTI-INFLAMMATORYQ2

SIRT1 EXPRESSIONQ1

DIABETESQ2

NEUROPATHYQ3

Abstract

Background and purpose: DIABETES mellitus is a metabolic disorder characterized byhyperglycemia, impaired insulin secretion or peripheral insulin resistance. Today, many herbal medicinesare used in treatment of DIABETES. Recently anti-diabetic properties of RESVERATROL are reported in somestudies, but none have evaluated its anti-neuropathy properties and its' effect on Sirt1 gene expression. The aim of this research was to investigate the anti-diabetic and anti-neuropathy properties of RESVERATROLin mice. Materials and methods: BALB/c mice were divided into 6 groups (n=6 per group). A singledose of 200mg/kg subcutaneous injection of STZ was used to induce DIABETES in all groups, except innegative controls which received normal saline. Treatment groups received metformin 300mg/kg andRESVERATROL 200mg/kg orally by gavage for 21 days. Then, their weight and blood sugar levels weredetermined and NEUROPATHY test was conducted by hot plate apparatus. After killing and removing theirlivers and RNA extraction, Sirt1 gene expression was assayed by Real-time PCR. Results: According to the findings, RESVERATROL significantly reduced blood sugar level andimproved peripheral NEUROPATHY which were comparable with metformin (P<0. 01). Moreover, Sirt1expression was increased by RESVERATROL. Conclusion: Based on these results, RESVERATROL could be used alongside other treatments ofdiabetes to decrease the degree of insulin resistance and NEUROPATHY.

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APA: Copy

SAED, AMIN, MOJTABAVI, SOMAYYEH, NAJAFI, MOJTABA, ZIAR, ALI, HAGHI, HAMED, & ATAEE, RAMIN. (2018). EVALUATION OF ANTI-DIABETIC AND ANTI-NEUROPATHY PROPERTIES OF RESVERATROL AND ITS EFFECT ON SIRT-1 EXPRESSION IN MICE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 27(157 ), 59-69. SID. https://sid.ir/paper/46021/en

Vancouver: Copy

SAED AMIN, MOJTABAVI SOMAYYEH, NAJAFI MOJTABA, ZIAR ALI, HAGHI HAMED, ATAEE RAMIN. EVALUATION OF ANTI-DIABETIC AND ANTI-NEUROPATHY PROPERTIES OF RESVERATROL AND ITS EFFECT ON SIRT-1 EXPRESSION IN MICE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;27(157 ):59-69. Available from: https://sid.ir/paper/46021/en

IEEE: Copy

AMIN SAED, SOMAYYEH MOJTABAVI, MOJTABA NAJAFI, ALI ZIAR, HAMED HAGHI, and RAMIN ATAEE, “EVALUATION OF ANTI-DIABETIC AND ANTI-NEUROPATHY PROPERTIES OF RESVERATROL AND ITS EFFECT ON SIRT-1 EXPRESSION IN MICE,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 157 , pp. 59–69, 2018, [Online]. Available: https://sid.ir/paper/46021/en

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