EVALUATION OF DRUG-INDUCED LIVER INJURY AND ITS RELATIONSHIP WITH NAT2 GENE POLYMORPHISMS IN TUBERCULOSIS PATIENTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

BABAMAHMOUDI FARHANG; KAMALABADI FARAHANI SAMANEH; RAMEZANI DARIUSH; AHANGAR NEMATOLLAH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Mazandaran University of Medical Sciences Year:2017 | Volume:27 | Issue:151 Page(s): 52-61

Download Full-Text

Persian Verion

View:

881

Download:

Cites:

Information Journal Paper

Title

EVALUATION OF DRUG-INDUCED LIVER INJURY AND ITS RELATIONSHIP WITH NAT2 GENE POLYMORPHISMS IN TUBERCULOSIS PATIENTS

Author(s)

BABAMAHMOUDI FARHANG | KAMALABADI FARAHANI SAMANEH | RAMEZANI DARIUSH | AHANGAR NEMATOLLAH | Issue Writer Certificate

Keywords

TUBERCULOSISQ3

LIVER INJURYQ1

ANTI-TUBERCULOSIS DRUGSQ2

NAT2Q1

POLYMORPHISMQ2

Abstract

Background and purpose: The main purpose of this study was determination of different genotypes and phenotypes of N-acetyltransferase 2 gene and its relationship with drug-induced LIVER INJURY among patients in Mazandaran province, Iran, which was done for the first time.Materials and methods: A total of 65 newly diagnosed unrelated pulmonary TUBERCULOSIS patients (47 men, 18 women) was enrolled in the study. A combination of polymerase chain reaction - restriction fragment length POLYMORPHISM method was used to investigate different allels of Nacetyltransferase- 2. The patients were followed for occurrence of antiTUBERCULOSIS induced hepatotoxicity during the course of treatment. Relationship between N-acetyltransferase-2 phenotypes and antiTUBERCULOSIS induced hepatotoxicity was evaluated.Results: Frequency of slow, intermediate and fast acetylator genotypes in patients were 34%, 60% and 6%, respectively. Hepatotoxicity was diagnosed in 13.64% of slow acetylators, in 2.56% of intermediate acetylators and interestingly in none of the fast acetylators. The Chi-Square Test showed no significant difference between different acetylation phenotypes and risk of hepatotoxicity (P = 0.1086).Conclusion: These results could improve treatment profile, prevent from drug-related adverse effects such as hepatotoxicty and lead to better outcomes in TUBERCULOSIS patients.

Cites

No record.

References

ANTITUBERCULOSIS DRUG-INDUCED HEPATOTOXICITY IN IRANIAN TUBERCULOSIS PATIENTS: ROLE OF ISONIAZID METABOLIC POLYMORPHISM

Cite

APA: Copy

BABAMAHMOUDI, FARHANG, KAMALABADI FARAHANI, SAMANEH, RAMEZANI, DARIUSH, & AHANGAR, NEMATOLLAH. (2017). EVALUATION OF DRUG-INDUCED LIVER INJURY AND ITS RELATIONSHIP WITH NAT2 GENE POLYMORPHISMS IN TUBERCULOSIS PATIENTS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 27(151), 52-61. SID. https://sid.ir/paper/46061/en

Vancouver: Copy

BABAMAHMOUDI FARHANG, KAMALABADI FARAHANI SAMANEH, RAMEZANI DARIUSH, AHANGAR NEMATOLLAH. EVALUATION OF DRUG-INDUCED LIVER INJURY AND ITS RELATIONSHIP WITH NAT2 GENE POLYMORPHISMS IN TUBERCULOSIS PATIENTS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;27(151):52-61. Available from: https://sid.ir/paper/46061/en

IEEE: Copy

FARHANG BABAMAHMOUDI, SAMANEH KAMALABADI FARAHANI, DARIUSH RAMEZANI, and NEMATOLLAH AHANGAR, “EVALUATION OF DRUG-INDUCED LIVER INJURY AND ITS RELATIONSHIP WITH NAT2 GENE POLYMORPHISMS IN TUBERCULOSIS PATIENTS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 151, pp. 52–61, 2017, [Online]. Available: https://sid.ir/paper/46061/en

Related Journal Papers