ASSOCIATION BETWEEN POLYMORPHISM OF INTERLEUKIN 17 (IL-17F) AND INCREASED SUSCEPTIBILITY TO GASTRIC CANCER

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GHORBANI ABOOZAR; HOSSEINI VAHID; AJAMI ABOLGHASEM; RAFIEI ALI REZA; HOSSEINI KHAH ZAHRA; JANBABAI GHASEM

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2012 | Volume:22 | Issue:91 Page(s): 11-20

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,283

Download:

Cites:

Information Journal Paper

Title

ASSOCIATION BETWEEN POLYMORPHISM OF INTERLEUKIN 17 (IL-17F) AND INCREASED SUSCEPTIBILITY TO GASTRIC CANCER

Author(s)

Keywords

GASTRIC CANCERQ2

GENE POLYMORPHISMQ2

IL-17FQ2

TH-17Q2

Abstract

Background and purpose: GASTRIC CANCER is one of the most common gastrointestinal cancers in the world. GASTRIC CANCER is the most common cancer in north of Iran. Interleukin-17F (IL-17F) is a proinflammatory cytokine expressed by a novel subset of CD4+Th cells (Th-17), and it causes the occurrence and strengthening the inflammatory response. This study aimed to assess the association between IL-17F- A7488G polymorphism and potential susceptibility to GASTRIC CANCER.Materials and methods: A case-control study consisting of 161 GASTRIC CANCER patients with mean age 62.14 ± 12.6 and 171 healthy controls with mean age 58.93 ± 14.2 was conducted. Genomic DNA was extracted and genotypes of - A7488G polymorphism were assessed through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).Results: The frequency of G allele was higher in GASTRIC CANCER patients (12.1%) compared with the control group (9.15%), but these differences were not significant (P═0.22). In addition, the distribution of GG genotype was not significantly differed between the patients and the controls (4.3% vs. 1.8%, P=0.182). Furthermore, logistic regression analysis revealed no significant association between the presence of 7488G allele and clinical stages (P=0.28), tumor grade (P=0.36) and H. pylori infection (P=0.89).Conclusion: These results suggest that IL-17F A7488G polymorphism in the promoter of IL-17F gene is not directly assumed as a genetic risk factor in the predisposition to GASTRIC CANCER.

Cites

No record.

References

No record.

Cite

APA: Copy

GHORBANI, ABOOZAR, HOSSEINI, VAHID, AJAMI, ABOLGHASEM, RAFIEI, ALI REZA, HOSSEINI KHAH, ZAHRA, & JANBABAI, GHASEM. (2012). ASSOCIATION BETWEEN POLYMORPHISM OF INTERLEUKIN 17 (IL-17F) AND INCREASED SUSCEPTIBILITY TO GASTRIC CANCER. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 22(91), 11-20. SID. https://sid.ir/paper/46080/en

Vancouver: Copy

GHORBANI ABOOZAR, HOSSEINI VAHID, AJAMI ABOLGHASEM, RAFIEI ALI REZA, HOSSEINI KHAH ZAHRA, JANBABAI GHASEM. ASSOCIATION BETWEEN POLYMORPHISM OF INTERLEUKIN 17 (IL-17F) AND INCREASED SUSCEPTIBILITY TO GASTRIC CANCER. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;22(91):11-20. Available from: https://sid.ir/paper/46080/en

IEEE: Copy

ABOOZAR GHORBANI, VAHID HOSSEINI, ABOLGHASEM AJAMI, ALI REZA RAFIEI, ZAHRA HOSSEINI KHAH, and GHASEM JANBABAI, “ASSOCIATION BETWEEN POLYMORPHISM OF INTERLEUKIN 17 (IL-17F) AND INCREASED SUSCEPTIBILITY TO GASTRIC CANCER,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 91, pp. 11–20, 2012, [Online]. Available: https://sid.ir/paper/46080/en

Related Journal Papers