The Role of MicroRNA-21 in Colorectal Cancer and Its Potential Value as a Predictive, Diagnostic and Prognostic Biomarker: A Review Article

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Ranjbarnejad Tayebeh; Ranjbarnejad Fatemeh; SAIDIJAM MASSOUD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Mazandaran University of Medical Sciences Year:2019 | Volume:28 | Issue:169 Page(s): 192-209

Download Full-Text

Persian Verion

View:

854

Download:

Cites:

Information Journal Paper

Title

The Role of MicroRNA-21 in Colorectal Cancer and Its Potential Value as a Predictive, Diagnostic and Prognostic Biomarker: A Review Article

Author(s)

Ranjbarnejad Tayebeh | Ranjbarnejad Fatemeh | SAIDIJAM MASSOUD | Issue Writer Certificate

Keywords

colorectal neoplasmsQ2

miR-21Q1

biomarkerQ1

Abstract

Colorectal cancer (CRC) is one of the most common types of cancers worldwide. Despite the improved therapeutic and diagnostic strategies and screening programs, morbidity and mortality of CRC is still considerable. Currently, most common approaches for diagnosis of CRC are colonoscopy and fecal occult blood test (FOBT). Because of the invasive nature of colonoscopy and low sensitivity of FOBT, it is essential to find precise and noninvasive methods for early diagnosis, monitoring, and control of colorectal cancer. In recent years, there has been growing interest in finding sensitive and non-invasive molecular biomarkers by evaluating expression profiles of miRNAs in patients with colorectal cancer. Many studies have shown the important role of microRNAs in regulating the expression of genes involved in tumorigenesis, which has led researchers to evaluate their ability in diagnosis and treatment of various cancers such as colorectal cancer. In this regard, miR-21 was studied in many researches. miR-21 is one of the earliest identified cancer-promoting ‘ oncomiRs’ , targeting numerous tumor suppressor genes associated with prolifera tion, apoptosis, and invasion. Overexpression of miR-21 is observed in colorectal cancer and some other cancers. Recent studies have focused on the diagnostic and prognostic value of miR-21 and its implication in drug resis tance of human cancers. The present study is a review of recent findings on the role of miR-21 in the regulation of target genes involved in colorectal carcinogenesis and its potential as a diagnostic and prognosis biomarker in this cancer.

Cites

No record.

References

Cite

APA: Copy

Ranjbarnejad, Tayebeh, Ranjbarnejad, Fatemeh, & SAIDIJAM, MASSOUD. (2019). The Role of MicroRNA-21 in Colorectal Cancer and Its Potential Value as a Predictive, Diagnostic and Prognostic Biomarker: A Review Article. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(169 ), 192-209. SID. https://sid.ir/paper/46104/en

Vancouver: Copy

Ranjbarnejad Tayebeh, Ranjbarnejad Fatemeh, SAIDIJAM MASSOUD. The Role of MicroRNA-21 in Colorectal Cancer and Its Potential Value as a Predictive, Diagnostic and Prognostic Biomarker: A Review Article. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;28(169 ):192-209. Available from: https://sid.ir/paper/46104/en

IEEE: Copy

Tayebeh Ranjbarnejad, Fatemeh Ranjbarnejad, and MASSOUD SAIDIJAM, “The Role of MicroRNA-21 in Colorectal Cancer and Its Potential Value as a Predictive, Diagnostic and Prognostic Biomarker: A Review Article,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 169 , pp. 192–209, 2019, [Online]. Available: https://sid.ir/paper/46104/en

Related Journal Papers