Relationship between C3435T MDR1 Gene Polymorphism and Treatment Response in Breast Cancer Patients

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HEDAYATIZADEH OMRAN AKBAR; ALIZADEH NAVAEI REZA; JANBABAEI GHASEM; AMJADI OMOLBANIN; Babaei Nasim; RAHMATPOUR ROKNI GHASEM; GODAZANDEH GHOLAMALI

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2019 | Volume:28 | Issue:169 Page(s): 98-107

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Title

Relationship between C3435T MDR1 Gene Polymorphism and Treatment Response in Breast Cancer Patients

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Keywords

breast cancerQ2

MDR1 geneQ3

gene polymorphismQ1

C3435TQ2

Abstract

Background and purpose breast cancer is the most common cancer in women. Most recently C3435T polymorphism of MDR1 gene is considered as one of the major causes of drug resistance in treatment of this disease. This study was conducted to investigate the relationship between C3435T MDR1 gene polymorphism and treatment response in breast cancer patients. Materials and methods In this longitudinal study, blood samples were collected from all cases and gene polymorphism was performed by PCR-RFLP method. Then, all patients underwent chemotherapy and patient response to treatment was evaluated. They were divided into two categories according to clinical response to treatment and lack of treatment response. Results This research included 152 women (mean age: 49. 84± 10. 95 years) with breast cancer. The genotype found more frequently was CT (49. 2%). Among the patients, 74. 3% responded to treatments and in 25. 7% there was no response to treatment. We found no significant differences between different genotypes in response to treatment (P=0. 485). Conclusion There was no direct relationship between the response of breast cancer to treatment and C3435T polymorphism of MDR1 gene.

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References

Prevalence of breast cancer among women over 30 years in Birjand between 2009 and 2010

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APA: Copy

HEDAYATIZADEH OMRAN, AKBAR, ALIZADEH NAVAEI, REZA, JANBABAEI, GHASEM, AMJADI, OMOLBANIN, Babaei, Nasim, RAHMATPOUR ROKNI, GHASEM, & GODAZANDEH, GHOLAMALI. (2019). Relationship between C3435T MDR1 Gene Polymorphism and Treatment Response in Breast Cancer Patients. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(169 ), 98-107. SID. https://sid.ir/paper/46119/en

Vancouver: Copy

HEDAYATIZADEH OMRAN AKBAR, ALIZADEH NAVAEI REZA, JANBABAEI GHASEM, AMJADI OMOLBANIN, Babaei Nasim, RAHMATPOUR ROKNI GHASEM, GODAZANDEH GHOLAMALI. Relationship between C3435T MDR1 Gene Polymorphism and Treatment Response in Breast Cancer Patients. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;28(169 ):98-107. Available from: https://sid.ir/paper/46119/en

IEEE: Copy

AKBAR HEDAYATIZADEH OMRAN, REZA ALIZADEH NAVAEI, GHASEM JANBABAEI, OMOLBANIN AMJADI, Nasim Babaei, GHASEM RAHMATPOUR ROKNI, and GHOLAMALI GODAZANDEH, “Relationship between C3435T MDR1 Gene Polymorphism and Treatment Response in Breast Cancer Patients,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 169 , pp. 98–107, 2019, [Online]. Available: https://sid.ir/paper/46119/en

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