SERUM LEVEL OF GHRELIN IN GIRLS WITH REAL PREMATURE PUBERTY BEFORE AND DURING TREATMENT WITH GNRH AGONISTS AND ITS ASSOCIATION WITH OBESITY

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ZAMANFAR DANIEL; ARABI MOHSEN; VAKILI RAHIM; GHAEMI NOSRAT; NEMATI MOHSEN; SHOKOHI LEILA

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Journal: Journal of Mazandaran University of Medical Sciences Year:2014 | Volume:24 | Issue:112 Page(s): 104-111

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Title

SERUM LEVEL OF GHRELIN IN GIRLS WITH REAL PREMATURE PUBERTY BEFORE AND DURING TREATMENT WITH GNRH AGONISTS AND ITS ASSOCIATION WITH OBESITY

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Keywords

GHRELINQ2

PRECOCIOUS PUBERTYQ3

OBESITYQ3

Abstract

Background and purpose: The PRECOCIOUS PUBERTY in girls can have some adverse effects such as growth stoppage and subsequent short stature in comparison with predicted final adult height. Gonadotropin-releasing hormone (GnRH) agonists are now considered as the treatment of CPP (Centeral PRECOCIOUS PUBERTY). One of the side effects of these drugs is increased appetite and consequently OBESITY. During puberty a progressive reduction in the level of GHRELIN has been reported. This study was aimed to assess the OBESITY and its association with GHRELIN in girls with true PRECOCIOUS PUBERTY treated with GnRH agonists.Materials and methods: A sample of 20 consecutive girls with true PRECOCIOUS PUBERTY was selected for this prospective observational study. They received 3.75 mg intramuscular GnRH every four weeks. Height, weight, body mass index (BMI), waist circumference, Tanner stage, body fat and serum GHRELIN, were measured at the time of entrance into the study and during the follow-up visits. The follow-up visits were carried out after 6 and 12 months.Results: Mean age of the studied 19 children was 87.5±10.1. Height and weight increased significantly after 6 and 12 months (P<0.01). The GHRELIN level and body fat percentage demonstrated no significant change during the 12 months follow-up (P>0.05). There was not any significant association between neither GHRELIN-BMI nor GHRELIN-body fat percentage (P>0.10).Conclusion: It seems that treatment with GnRHa is effective. More importantly patients with increased BMI may need appropriate dietary consultation to accomplish their weight control during the course of the treatment.

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APA: Copy

ZAMANFAR, DANIEL, ARABI, MOHSEN, VAKILI, RAHIM, GHAEMI, NOSRAT, NEMATI, MOHSEN, & SHOKOHI, LEILA. (2014). SERUM LEVEL OF GHRELIN IN GIRLS WITH REAL PREMATURE PUBERTY BEFORE AND DURING TREATMENT WITH GNRH AGONISTS AND ITS ASSOCIATION WITH OBESITY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 24(112), 104-111. SID. https://sid.ir/paper/46215/en

Vancouver: Copy

ZAMANFAR DANIEL, ARABI MOHSEN, VAKILI RAHIM, GHAEMI NOSRAT, NEMATI MOHSEN, SHOKOHI LEILA. SERUM LEVEL OF GHRELIN IN GIRLS WITH REAL PREMATURE PUBERTY BEFORE AND DURING TREATMENT WITH GNRH AGONISTS AND ITS ASSOCIATION WITH OBESITY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;24(112):104-111. Available from: https://sid.ir/paper/46215/en

IEEE: Copy

DANIEL ZAMANFAR, MOHSEN ARABI, RAHIM VAKILI, NOSRAT GHAEMI, MOHSEN NEMATI, and LEILA SHOKOHI, “SERUM LEVEL OF GHRELIN IN GIRLS WITH REAL PREMATURE PUBERTY BEFORE AND DURING TREATMENT WITH GNRH AGONISTS AND ITS ASSOCIATION WITH OBESITY,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 112, pp. 104–111, 2014, [Online]. Available: https://sid.ir/paper/46215/en

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