EVALUATION OF PERIPHERAL BLOOD NEUTROPHIL SURVIVAL FOLLOWING TREATMENT WITH MESENCHYMAL STEM CELLS IN RATS

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HAMOUNNAVARD SAHAR; DELIREZH NOWRUZ; AFZAL AHANGARAN NAHIDEH

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2014 | Volume:24 | Issue:112 Page(s): 34-40

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Title

EVALUATION OF PERIPHERAL BLOOD NEUTROPHIL SURVIVAL FOLLOWING TREATMENT WITH MESENCHYMAL STEM CELLS IN RATS

Author(s)

HAMOUNNAVARD SAHAR | DELIREZH NOWRUZ | AFZAL AHANGARAN NAHIDEH | Issue Writer Certificate

Keywords

MESENCHYMAL STEM CELLSQ2

NEUTROPHILQ2

SURVIVALQ1

Abstract

Background and purpose: Because of theirmultipotency and ease of purification, amplification and immunomodulatory properties MESENCHYMAL STEM CELLS (MSC), are anideal stem cell source for cell therapies. This study was done to investigat the effect of Rat MSCs on the SURVIVAL NEUTROPHILs.Materials and methods: MSCs was isolated from rat (6-8 weeks) femoral and tibial bone marrow and cultured in DMEM. Then maturation MSCs were incubated with NEUTROPHILs isolated from peripheral blood of rat at 37oC for 1 h. NEUTROPHIL SURVIVAL was measured at 6 and 24 h incubation with of MSCs by flow cytometric analysis using An/PI. Data were analyzed by SPSS software, followed by Tukeytest at a significance level of (P<0.05).Results: The 6-hour incubation of NEUTROPHILs with MSCs, significantly reduced the percentage of normal cells and increased apoptosis compared to controls and increased cell necrosis was not significant in the treated group than in control. The 24-hour incubation of NEUTROPHILs with MSCs, significantly increased the percentage of healthy cells and apoptosis was reduced compared to the control group, and reduced cell necrosis was not significant in the treated groups than in control (p<0.05).Conclusion: In spite of the clinical importance of MSCs, some biological aspects of them including their self-renewal, proliferation and immune modulatory effects are of great therapeutic potential for cell therapy.

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APA: Copy

HAMOUNNAVARD, SAHAR, DELIREZH, NOWRUZ, & AFZAL AHANGARAN, NAHIDEH. (2014). EVALUATION OF PERIPHERAL BLOOD NEUTROPHIL SURVIVAL FOLLOWING TREATMENT WITH MESENCHYMAL STEM CELLS IN RATS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 24(112), 34-40. SID. https://sid.ir/paper/46220/en

Vancouver: Copy

HAMOUNNAVARD SAHAR, DELIREZH NOWRUZ, AFZAL AHANGARAN NAHIDEH. EVALUATION OF PERIPHERAL BLOOD NEUTROPHIL SURVIVAL FOLLOWING TREATMENT WITH MESENCHYMAL STEM CELLS IN RATS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;24(112):34-40. Available from: https://sid.ir/paper/46220/en

IEEE: Copy

SAHAR HAMOUNNAVARD, NOWRUZ DELIREZH, and NAHIDEH AFZAL AHANGARAN, “EVALUATION OF PERIPHERAL BLOOD NEUTROPHIL SURVIVAL FOLLOWING TREATMENT WITH MESENCHYMAL STEM CELLS IN RATS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 112, pp. 34–40, 2014, [Online]. Available: https://sid.ir/paper/46220/en

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