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Information Journal Paper

Title

LEVELS OF IL-6 AND TUMOR NECROSIS FACTOR-α IN SEMINAL FLUID SPERMATIC VEIN AND PERIPHERAL BLOOD OF PATIENT WITH VARICOCELE

Pages

  13-17

Abstract

 Background and Objectives: Human sperm contains a wide spectrum of cytokines; such as INTERLEUKIN-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha). Their effects on semen quality are still under debate. This study aims at assessing possible association of these two cytokins with semen characteristics in patients with grade II-III VARICOCELE.Materials and Methods: In this analytic-descriptive study, 30 male patients with grade II-III VARICOCELE were recruited in Tabriz Sina Hospital within a 12-month period. Levels of IL-6 and TNF-alpha were measured in seminal plasma, spermatic vein sample and peripheral serum specimen. Correlations between these parameters and sperm count, motility and morphology were assessed.Results: The mean levels of IL-6 were 23.73±9.02, 28.73±11.98 and 38.20±13.28 pg/mL in specimens from peripheral serum, spermatic vein and seminal plasma, respectively. The mean levels of TNF-alpha were 4.78±1.91, 5.66±2.95 and 6.45±2.55 pg/mL in specimens from peripheral serum, spermatic vein and seminal plasma, respectively. The mean seminal plasma IL-6 level was significantly higher in the cases with grade III VARICOCELE. There were significant negative correlations between seminal plasma IL-6 and sperm count (r=-0.46, P=0.01) and motility (r=-0.38, P=0.04). There was no significant correlation between the spermatic vein and peripheral serum IL-6 or seminal plasma, spermatic vein and peripheral serum TNF-alpha with the spermatozoal parameters.Conclusion: Seminal plasma IL-6 is associated with worse spermatozoal parameters in seminal analysis of patients with grade II-III VARICOCELE.

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    APA: Copy

    AHMADI ASRE BADR, YADOLLAH, FAREGHI, MEHDI, HAJIR, SAMAD, NOURI, MOHAMMAD, KHODABAKHSH, FATEME, & FADAEI FOULADI, ROHOLLAH. (2012). LEVELS OF IL-6 AND TUMOR NECROSIS FACTOR-α IN SEMINAL FLUID SPERMATIC VEIN AND PERIPHERAL BLOOD OF PATIENT WITH VARICOCELE. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 34(4), 13-17. SID. https://sid.ir/paper/46571/en

    Vancouver: Copy

    AHMADI ASRE BADR YADOLLAH, FAREGHI MEHDI, HAJIR SAMAD, NOURI MOHAMMAD, KHODABAKHSH FATEME, FADAEI FOULADI ROHOLLAH. LEVELS OF IL-6 AND TUMOR NECROSIS FACTOR-α IN SEMINAL FLUID SPERMATIC VEIN AND PERIPHERAL BLOOD OF PATIENT WITH VARICOCELE. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;34(4):13-17. Available from: https://sid.ir/paper/46571/en

    IEEE: Copy

    YADOLLAH AHMADI ASRE BADR, MEHDI FAREGHI, SAMAD HAJIR, MOHAMMAD NOURI, FATEME KHODABAKHSH, and ROHOLLAH FADAEI FOULADI, “LEVELS OF IL-6 AND TUMOR NECROSIS FACTOR-α IN SEMINAL FLUID SPERMATIC VEIN AND PERIPHERAL BLOOD OF PATIENT WITH VARICOCELE,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 34, no. 4, pp. 13–17, 2012, [Online]. Available: https://sid.ir/paper/46571/en

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