SEXUAL DYSFUNCTION OF MEN ON METHADONE MAINTENANCE TREATMENT MMT AND ITS, RELATION WITH METHADONE DOSE AND BLOOD LEVEL OF TESTOSTERONE AND PROLACTINE

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KHEIRABADI GOLAM REZA; SALEHI MEHRDAD; GOLAFSHAN NASER; MARACY MOHAMMAD REZA

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Journal: MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES Year:2012 | Volume:34 | Issue:4 Page(s): 68-73

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Title

SEXUAL DYSFUNCTION OF MEN ON METHADONE MAINTENANCE TREATMENT MMT AND ITS, RELATION WITH METHADONE DOSE AND BLOOD LEVEL OF TESTOSTERONE AND PROLACTINE

Author(s)

KHEIRABADI GOLAM REZA | SALEHI MEHRDAD | GOLAFSHAN NASER | MARACY MOHAMMAD REZA | Issue Writer Certificate

Keywords

TREATMENTQ2

MAINTENANCEQ3

SEXUALQ2

METHADONEQ2

PROLACTINQ2

TESTOSTERONEQ3

Abstract

Background and Objectives: METHADONE induced SEXUAL dysfunction is one of the main reasons of noncompliance with METHADONE therapy. This study was designed to evaluate the relation between SEXUAL function with METHADONE Dosage, and TESTOSTERONE and PROLACTIN Plasma levels.Materials and Methods: In a cross sectional study, 135 patients on MMT from 2 MMT centers were allocated with a simple random sampling method after getting a written consent form. Beck Depression Inventory (BDI) and International Index of Erectile Function (IIEF) were completed by the patients, and then a blood sample was taken for laboratory measurement of TESTOSTERONE and PROLACTIN. Collected data was analyzed using the statistical methods.Results: The mean age of patients was 36.38±9.44 years, 94.8% of participants had some degrees of SEXUAL dysfunction, Mean METHADONE dosage was 100.2±38.4 Mg/day and Serum TESTOSTERONE and PROLACTIN levels were, 8.7±6.6 and 4.8±3.1 Microgram/Lit respectively. There was no significant association between mean of IIEF score with METHADONE dosage (r=-0.021, P=0.8) and TESTOSTERONE level (r=-0.101, P=0.25) but There was significant association between mean of IIEF score and PROLACTIN levels (r=-0.18, P=0.039). On multiple regression test, only PROLACTIN plasma levels was a significant predictive of IIEF score.Conclusion: Plasma PROLACTIN levels are the only SEXUAL function Predictor of patients on MMT regimen.

Cites

EXECUTIVE FUNCTIONS OF PATIENTS UNDER METHADONE AND BUPRENORPHINE MAINTENANCE TREATMENT

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APA: Copy

KHEIRABADI, GOLAM REZA, SALEHI, MEHRDAD, GOLAFSHAN, NASER, & MARACY, MOHAMMAD REZA. (2012). SEXUAL DYSFUNCTION OF MEN ON METHADONE MAINTENANCE TREATMENT MMT AND ITS, RELATION WITH METHADONE DOSE AND BLOOD LEVEL OF TESTOSTERONE AND PROLACTINE. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 34(4), 68-73. SID. https://sid.ir/paper/46577/en

Vancouver: Copy

KHEIRABADI GOLAM REZA, SALEHI MEHRDAD, GOLAFSHAN NASER, MARACY MOHAMMAD REZA. SEXUAL DYSFUNCTION OF MEN ON METHADONE MAINTENANCE TREATMENT MMT AND ITS, RELATION WITH METHADONE DOSE AND BLOOD LEVEL OF TESTOSTERONE AND PROLACTINE. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;34(4):68-73. Available from: https://sid.ir/paper/46577/en

IEEE: Copy

GOLAM REZA KHEIRABADI, MEHRDAD SALEHI, NASER GOLAFSHAN, and MOHAMMAD REZA MARACY, “SEXUAL DYSFUNCTION OF MEN ON METHADONE MAINTENANCE TREATMENT MMT AND ITS, RELATION WITH METHADONE DOSE AND BLOOD LEVEL OF TESTOSTERONE AND PROLACTINE,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 34, no. 4, pp. 68–73, 2012, [Online]. Available: https://sid.ir/paper/46577/en

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