SERUM CERULOPLASMIN LEVELS AS AN INDEX OF ANTIOXIDANT CAPACITY IN FULLTERM AND PREMATURE NEONATES

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RAHBANI NOUBAR M.; RAHBANI NOUBAR M.E.

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Journal: Medical Journal of Tabriz University of Medical Sciences Year:2001 | Volume:35 | Issue:51 Page(s): 41-44

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Title

SERUM CERULOPLASMIN LEVELS AS AN INDEX OF ANTIOXIDANT CAPACITY IN FULLTERM AND PREMATURE NEONATES

Author(s)

RAHBANI NOUBAR M. | RAHBANI NOUBAR M.E. | Issue Writer Certificate

Keywords

CERULOPLASMINQ3

FULL TERM NEWBORNQ4

PREMATURE NEWBORNQ3

SUPPORTIVE OXYGEN THERAPYQ4

Abstract

Background and Objectives: Oxygen radical injury may be a common pathogenic mechanism in several neonatal diseases. Oxygen toxicity is a major problem during the postnatal adaptation period especially among premature infants. While reactive oxygen free radical are generated continuously either in hypoxic state or during the SUPPORTIVE OXYGEN THERAPY, which is frequently used in these patients, their antioxidant defense mechanisms are inadequate. Since CERULOPLASMIN (Cp) is an important extracellular antioxidant and vitally important in regulating the ionic state of iron particularly oxidizing Fe2+ to Fe3+, its concentration and enzymic activity can be of great significance on the first day of life.Materials and Methods: Cp oxidase activity and its concentrection in cord blood of full term and premature neonates were measured by manual kinetic method using p - phenylene diamine as substrate and immunochemical technic respectively.Results:The mean activity of enzyme in the cord blood sera from 52 term neonates was 200 HU/L(range 81-300 HU/L) while, in the samples of 50 premature infants it was 110 HU/L (range 0-290 HU/L). The concentration of Cp in the groups were 12 mg/dl (range 7-28 mg/dl) and 8mg/dl (0-18 mg/dl) respectively. After SUPPORTIVE OXYGEN THERAPY the oxidase activity of the CERULOPLASMIN and its apoenzyme concentration again were measured in 25 cases of premature infants. Comparing with the rest of the premature infants significant reduction (p<0.05) was noticed in the oxidase activity of enzyme without any marked decrease in the apoenzyme concentration.Conclusion: It can be concluded from this study that CERULOPLASMIN measurement is an index of antioxidant capacity of neonate and if oxygen is to be administered to these babies, they should simultaneously receive injection of Vitamin C to protect them from reactive oxygen species (ROS).

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APA: Copy

RAHBANI NOUBAR, M., & RAHBANI NOUBAR, M.E.. (2001). SERUM CERULOPLASMIN LEVELS AS AN INDEX OF ANTIOXIDANT CAPACITY IN FULLTERM AND PREMATURE NEONATES. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 35(51), 41-44. SID. https://sid.ir/paper/46590/en

Vancouver: Copy

RAHBANI NOUBAR M., RAHBANI NOUBAR M.E.. SERUM CERULOPLASMIN LEVELS AS AN INDEX OF ANTIOXIDANT CAPACITY IN FULLTERM AND PREMATURE NEONATES. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2001;35(51):41-44. Available from: https://sid.ir/paper/46590/en

IEEE: Copy

M. RAHBANI NOUBAR, and M.E. RAHBANI NOUBAR, “SERUM CERULOPLASMIN LEVELS AS AN INDEX OF ANTIOXIDANT CAPACITY IN FULLTERM AND PREMATURE NEONATES,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 35, no. 51, pp. 41–44, 2001, [Online]. Available: https://sid.ir/paper/46590/en

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