EFFECT OF INTERFERON BETA - 1-A ON BRAIN LESIONS IN MRI IMAGES IN MULTIPLE SCLEROSIS

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PASHAPOUR A.; MANSORIZADEH R.; DAGHIGHI M.

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Journal: Medical Journal of Tabriz University of Medical Sciences Year:2006 | Volume:27 | Issue:4 Page(s): 17-21

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Title

EFFECT OF INTERFERON BETA - 1-A ON BRAIN LESIONS IN MRI IMAGES IN MULTIPLE SCLEROSIS

Author(s)

PASHAPOUR A. | MANSORIZADEH R. | DAGHIGHI M. | Issue Writer Certificate

Keywords

INTERFERONQ3

MULTIPLE SCLEROSISQ2

DEMYELINATIONQ4

MRIQ4

Abstract

Background and Objective: MULTIPLE SCLEROSIS (MS) is a T cell- mediated autoimmune disease with central nervous system lesions which characterized by mononuclear cellular infiltrate, edema, DEMYELINATION, and occasionally axonal loss. MS is a chronic disease requiring long-term monitoring of treatment. This study performed to evaluate the effects of INTERFERON beta - Ia on brain lesions of MS patients by then MRI images.Materials and Methods: In this study, 30 patients who had MS criteria were selected.Neurologic examinations were done on them and primary MRI was preformed. Then they were treated with INTERFERON beta-1 a for six months. After then, another MRI was preformed and neurologic reexamination done again. We compared results of first and second MRIs and examinations results were analyzed with SPSS, Paired T-test & Chi-square. Results were reported in percents and means. The level of meaningfulness was considered as P<0.05.Results: Out of 30 patients, 22 of them were female and 8 of them were males. Mean age at the time of study was 31.2 (SD=5/68) years. There were, decrease of motor signs in 13 cases, decrease of sensory signs in 5 cases, decrease of cerebellar & brain stem signs in 5 cases and decrease of spinal signs in 7 cases. There was decrease in the size of MRI plaques in supratentorium in 17 cases, in cerebellum and brain stem in 14 cases, and in cervical cord in 4 cases. There was decreased number of MRI plaques in supratentorium in 4 cases, cerebellum and brain stem in 10 cases and in spine in 2 cases. In first MRI number of lesions were in 30 cases in supratentorium, 13 cases in infratentorium and 13 cases in spine. Conclusions: INTERFERON beta-la is effective in decreasing the size of MRI plaques in MS patients. Also it is useful in decreasing clinical signs.

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APA: Copy

PASHAPOUR, A., MANSORIZADEH, R., & DAGHIGHI, M.. (2006). EFFECT OF INTERFERON BETA - 1-A ON BRAIN LESIONS IN MRI IMAGES IN MULTIPLE SCLEROSIS. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 27(4), 17-21. SID. https://sid.ir/paper/46651/en

Vancouver: Copy

PASHAPOUR A., MANSORIZADEH R., DAGHIGHI M.. EFFECT OF INTERFERON BETA - 1-A ON BRAIN LESIONS IN MRI IMAGES IN MULTIPLE SCLEROSIS. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;27(4):17-21. Available from: https://sid.ir/paper/46651/en

IEEE: Copy

A. PASHAPOUR, R. MANSORIZADEH, and M. DAGHIGHI, “EFFECT OF INTERFERON BETA - 1-A ON BRAIN LESIONS IN MRI IMAGES IN MULTIPLE SCLEROSIS,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 4, pp. 17–21, 2006, [Online]. Available: https://sid.ir/paper/46651/en

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