RENAL INVOLVEMENT IN DIFFERENT GENOTYPES OF FAMILIAL MEDITERRANEAN FEVER A REPORT FROM AZERBAIJAN PROVINCE

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GHANBARI MARYAM; ARDALAN MOHAMMAD REZA; JABBAR POUR BONYADI MORTAZA; RAHMANI SEYED HESAM

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Journal: Medical Journal of Tabriz University of Medical Sciences Year:2013 | Volume:35 | Issue:4 Page(s): 58-62

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Title

RENAL INVOLVEMENT IN DIFFERENT GENOTYPES OF FAMILIAL MEDITERRANEAN FEVER A REPORT FROM AZERBAIJAN PROVINCE

Author(s)

GHANBARI MARYAM | ARDALAN MOHAMMAD REZA | JABBAR POUR BONYADI MORTAZA | RAHMANI SEYED HESAM | Issue Writer Certificate

Keywords

FAMILIAL MEDITERRANEAN FEVERQ2

AMYLOIDOSISQ2

PROTEINURIAQ3

RENAL INVOLVEMENTQ2

Abstract

Background and Objectives: FAMILIAL MEDITERRANEAN FEVER (FMF) is a hereditary disorder characterized by recurrent self-limited attacks of fever and polyserositis. The disease is associated with mutations in the (MEFV) gene. The M694V mutation carries a significant risk for AMYLOIDOSIS. The purpose of this study was to evaluated RENAL INVOLVEMENT in different genotypes of FAMILIAL MEDITERRANEAN FEVER among patients diagnosed in East Azerbaijan state.Material and Methods: Five hundred genetically identified FMF patients were included in our study and their demographic Characteristics, clinical manifestation and laboratory findings were studied respectively. According to their genotype and heterozygocity or homozygocity patients were divided into 4 groups (M694V/M694V, M694V/other, other/other, E148Q/other). RENAL INVOLVEMENT defined by the presence of glomerular hematuria and persistent PROTEINURIA unrelated to other conations.Results: Among our cohort we discovered nine patients (1.8%; M/F: 5/4) with RENAL INVOLVEMENT. Eight of them Kidney biopsy was performed and it was compatible with AMYLOIDOSIS. One patient had acute glomerulonephritis with meningeal proliferation and these patients had E148Q mutation. The most frequent mutation among other patients was M694V (42%).Conclusion: The results of this study showed that in other ethnicities ‘like previously reported results M694V mutation is the most important genetic factor for RENAL INVOLVEMENT in FMF.

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APA: Copy

GHANBARI, MARYAM, ARDALAN, MOHAMMAD REZA, JABBAR POUR BONYADI, MORTAZA, & RAHMANI, SEYED HESAM. (2013). RENAL INVOLVEMENT IN DIFFERENT GENOTYPES OF FAMILIAL MEDITERRANEAN FEVER A REPORT FROM AZERBAIJAN PROVINCE. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 35(4), 58-62. SID. https://sid.ir/paper/46742/en

Vancouver: Copy

GHANBARI MARYAM, ARDALAN MOHAMMAD REZA, JABBAR POUR BONYADI MORTAZA, RAHMANI SEYED HESAM. RENAL INVOLVEMENT IN DIFFERENT GENOTYPES OF FAMILIAL MEDITERRANEAN FEVER A REPORT FROM AZERBAIJAN PROVINCE. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2013;35(4):58-62. Available from: https://sid.ir/paper/46742/en

IEEE: Copy

MARYAM GHANBARI, MOHAMMAD REZA ARDALAN, MORTAZA JABBAR POUR BONYADI, and SEYED HESAM RAHMANI, “RENAL INVOLVEMENT IN DIFFERENT GENOTYPES OF FAMILIAL MEDITERRANEAN FEVER A REPORT FROM AZERBAIJAN PROVINCE,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 35, no. 4, pp. 58–62, 2013, [Online]. Available: https://sid.ir/paper/46742/en

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