EFFECT OF AMLODIPINE ON HEART TISSUE CONCENTRATION OF ENDOTHELIN IN RABBITS RECEIVING ATHEROGENIC DIET

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MOHAMMADI MOSTAFA; SALEHI IRAJ; MIRZAEI FARIBA; ASLANABADI N.; BABAEI HOSSEIN; BONYADI M.R.

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Journal: Medical Journal of Tabriz University of Medical Sciences Year:2008 | Volume:30 | Issue:1 Page(s): 105-109

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Title

EFFECT OF AMLODIPINE ON HEART TISSUE CONCENTRATION OF ENDOTHELIN IN RABBITS RECEIVING ATHEROGENIC DIET

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Keywords

ATHEROSCLEROSISQ2

AMLODIPINE. ENDOTHELIN-1Q3

HEART TISSUEQ3

Abstract

Background and Objectives: During recent years many factors has increased the nonepidemic diseases including cardiovascular ones. ATHEROSCLEROSIS is one of the main causes of cardiovascular diseases. Some researchers suggested that calcium channel blockers can slowdown the process of ATHEROSCLEROSIS Materials and Methods: Thirty six male Newsland white rabbits were divided into four groups: The normal control group, normal group receiving amlodipine, and high-cholesterol diet group and high-cholesterol diet with amlodipine group. After 8 weeks all animals anesthetized and blood and tissues samples were colleted.Results: Amlodipine consumption in eight weeks reduced significantly (P<0.01) plasma endothelin-1 levels in both of high-cholesterol diet plus amlodipine and amlodipine groups. Amlodipine consumption caused significant reduction (P<0/01) in the level of endothelin-1 in HEART TISSUE of high-cholesterol diet plus amlodipine group but did no effect on reduction of HEART TISSUE endothelin-1 in amlodipine group.Conclusion: High-cholesterol diet caused enhancing of plasma and HEART TISSUE endothelin-1 and amlodipine reduced plasma and tissue endothelin-1 levels in high-cholesterol diet group. In conclusion amlodipine treatment could have positive effects in pathology of heart diseases.

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APA: Copy

MOHAMMADI, MOSTAFA, SALEHI, IRAJ, MIRZAEI, FARIBA, ASLANABADI, N., BABAEI, HOSSEIN, & BONYADI, M.R.. (2008). EFFECT OF AMLODIPINE ON HEART TISSUE CONCENTRATION OF ENDOTHELIN IN RABBITS RECEIVING ATHEROGENIC DIET. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 30(1), 105-109. SID. https://sid.ir/paper/46872/en

Vancouver: Copy

MOHAMMADI MOSTAFA, SALEHI IRAJ, MIRZAEI FARIBA, ASLANABADI N., BABAEI HOSSEIN, BONYADI M.R.. EFFECT OF AMLODIPINE ON HEART TISSUE CONCENTRATION OF ENDOTHELIN IN RABBITS RECEIVING ATHEROGENIC DIET. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2008;30(1):105-109. Available from: https://sid.ir/paper/46872/en

IEEE: Copy

MOSTAFA MOHAMMADI, IRAJ SALEHI, FARIBA MIRZAEI, N. ASLANABADI, HOSSEIN BABAEI, and M.R. BONYADI, “EFFECT OF AMLODIPINE ON HEART TISSUE CONCENTRATION OF ENDOTHELIN IN RABBITS RECEIVING ATHEROGENIC DIET,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 30, no. 1, pp. 105–109, 2008, [Online]. Available: https://sid.ir/paper/46872/en

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