EFFICACY OF UTERAL INJECTION OF G-CSF IN REPEATED IMPLANTATION FAILURE: A CLINICAL TRIAL STUDY

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JALILVAND FARANAK; GHASEMZADEH ALIEH; HAMDI KOBRA; NAVALI NAZLI; PIA HELEN; FARZADI LAYA

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Journal: MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:40 | Issue:1 Page(s): 17-21

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Title

EFFICACY OF UTERAL INJECTION OF G-CSF IN REPEATED IMPLANTATION FAILURE: A CLINICAL TRIAL STUDY

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Keywords

IN VITRO FERTILIZATIONQ2

INFERTILITYQ2

G-CSFQ3

CLINICAL TRIALQ2

Abstract

Background: Despite advances in clinical and laboratory techniques, including stimulating ovulation and transferring embryo, success rate of pregnancy remains is about 30%. The aim of this study was to assess the effect of intra uterine G-CSF on implantation and clinical pregnancy rate in patients with implantation failure in IVF. Methods: This study was a randomized CLINICAL TRIAL on patients undergoing IN VITRO FERTILIZATION within an age range of 45-18 years and a history of failure in implantation for two or more times. A total of 34 patients receiving G-CSF in the intervention group and 38 patients in the control group were enrolled. Results: Mean age of the participants was 34. 1 years with a standard deviation of 6. 4 years. The average number of years of fertility was 10 years with a standard deviation of 5. 2 years. The average number of embryos implanted in the intervention group was 2. 88 with a standard deviation of 0. 33. The figures for the control group were 2. 97 and 0. 37, respectively. The two groups did not differ significantly. With respect to the potential clinical and laboratory fertility outcomes, including existing gestational sac with observed heart rate and positive serum β HCG, no statistically significant difference was observed between the two groups. Conclusion: It seems that the effect of G-CSF on improving fertility outcomes in patients with implantation failure does not exist and more related studies are recommended in this regard.

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APA: Copy

JALILVAND, FARANAK, GHASEMZADEH, ALIEH, HAMDI, KOBRA, NAVALI, NAZLI, PIA, HELEN, & FARZADI, LAYA. (2018). EFFICACY OF UTERAL INJECTION OF G-CSF IN REPEATED IMPLANTATION FAILURE: A CLINICAL TRIAL STUDY. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 40(1 ), 17-21. SID. https://sid.ir/paper/46895/en

Vancouver: Copy

JALILVAND FARANAK, GHASEMZADEH ALIEH, HAMDI KOBRA, NAVALI NAZLI, PIA HELEN, FARZADI LAYA. EFFICACY OF UTERAL INJECTION OF G-CSF IN REPEATED IMPLANTATION FAILURE: A CLINICAL TRIAL STUDY. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;40(1 ):17-21. Available from: https://sid.ir/paper/46895/en

IEEE: Copy

FARANAK JALILVAND, ALIEH GHASEMZADEH, KOBRA HAMDI, NAZLI NAVALI, HELEN PIA, and LAYA FARZADI, “EFFICACY OF UTERAL INJECTION OF G-CSF IN REPEATED IMPLANTATION FAILURE: A CLINICAL TRIAL STUDY,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 40, no. 1 , pp. 17–21, 2018, [Online]. Available: https://sid.ir/paper/46895/en

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