EFFICACY OF LOCAL STEROID COMPARED WITH ANTIHISTAMIN IN ALLERGIC RHINITIS

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SEYED TOTONCHI S.J.; SEYED TOTONCHI S.A.

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Journal: MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES Year:2001 | Volume:35 | Issue:49 Page(s): 27-32

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Title

EFFICACY OF LOCAL STEROID COMPARED WITH ANTIHISTAMIN IN ALLERGIC RHINITIS

Author(s)

SEYED TOTONCHI S.J. | SEYED TOTONCHI S.A. | Issue Writer Certificate

Keywords

ALLERGIC RHINITISQ2

ANTIHISTAMINQ4

LOCAL STEROIDQ3

Abstract

Background and Objectives: ALLERGIC RHINITIS is the most common presentation of atopic disorders, and one of the important causes of morbidity, but much under diagnosed (Atopy are the special antibodies against one or more common allergen that become distinct with skin test).Economic consequences of ALLERGIC RHINITIS is considerable . About 20 million persons in America suffer from this disorder. Economic consequences of ALLERGIC RHINITIS is 500 million dollar in America every year. In England and American studies allergic incidences varies from 3.2% to 18%. Although this disorder has not been much studied in our country, however, it is estimated that about 10% patients suffers from the disease .Methodology: In this study we compared LOCAL STEROIDs (Betamethasone drop) versus systemic ANTIHISTAMINic (Dexchlorpheniramin) effects in ALLERGIC RHINITIS symptoms and single blind form. The study was conducted on 72 patients, in Group I (Antihistaminic Group) which comprised of 36 patients , dexchlorpheniramin (2 mg Tid) was given for one month, and in Group II (n=36) the patients received betamethasone drop (2 drop every 8 hour) for period of one month.Selection of drug was intermittent. After treatment, symptoms and signs in two groups were compared with each other. The most common sign before begining of treatment was nasal congestion (95.%8 ), which after treatment with ANTIHISTAMINes declined to 18% and with usuage of LOCAL STEROIDs it reduced to 8%. Results and Conclusion: LOCAL STEROIDs recover symptoms and signs as PND, weakness and chornea hypertrophy better than systemic ANTIHISTAMINics. However, in symptoms and signs such as headache, congestion, local pruritus and rhinorrhea these two drugs have the same effects. The distinguishable difference was observed in the treatment with steroids, usuage of which reduced symptoms from 80% to 3% whereas, in group with ANTIHISTAMINs symptoms reduced from 80% to 50% in only 58% cases. In our view, ALLERGIC RHINITIS better responds to LOCAL STEROIDs.

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APA: Copy

SEYED TOTONCHI, S.J., & SEYED TOTONCHI, S.A.. (2001). EFFICACY OF LOCAL STEROID COMPARED WITH ANTIHISTAMIN IN ALLERGIC RHINITIS . MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 35(49), 27-32. SID. https://sid.ir/paper/47059/en

Vancouver: Copy

SEYED TOTONCHI S.J., SEYED TOTONCHI S.A.. EFFICACY OF LOCAL STEROID COMPARED WITH ANTIHISTAMIN IN ALLERGIC RHINITIS . MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2001;35(49):27-32. Available from: https://sid.ir/paper/47059/en

IEEE: Copy

S.J. SEYED TOTONCHI, and S.A. SEYED TOTONCHI, “EFFICACY OF LOCAL STEROID COMPARED WITH ANTIHISTAMIN IN ALLERGIC RHINITIS ,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 35, no. 49, pp. 27–32, 2001, [Online]. Available: https://sid.ir/paper/47059/en

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