ANTINOCICEPTIVE EFFECT OF HERACLEUM PERSICUM LEAF HYDROETHANOLIC EXTRACT IN DIABETIC MALE MICE

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Moharerizadeh Tayebeh; Mirazi Nasere

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Journal: MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:39 | Issue:5 Page(s): 57-64

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Title

ANTINOCICEPTIVE EFFECT OF HERACLEUM PERSICUM LEAF HYDROETHANOLIC EXTRACT IN DIABETIC MALE MICE

Author(s)

Moharerizadeh Tayebeh | Mirazi Nasere | Issue Writer Certificate

Keywords

HERACLEUMPERSICUMQ1

PAINQ2

DIABETESQ3

STREPTOZOTOCINQ2

MICEQ2

Abstract

Background: PAIN is a protective sense in tissue injury time. DIABETES mellitus accompanies with undesirable neuropathic side-effects in long term. The aim of this study was to examine analgesic effects of hydroethanolic HERACLEUMPERSICUML. leaf’ s extract (HHE) in diabetic and intact male MICE. Methods: 96 male MICE were divided into 9 groups: control, treated by morphine, treated by HHE (100, 200 and 400mg/kg, i. p. ), naloxone + HHE(200mg/kg) and STZ (60mg/kg, i. p) and STZ+ HHE(400mg/kg) randomly. To assess the antinociceptive effects of HHE, the animals were examined by tail-flick and writhing tests. Results: 200 and 400 mg/kg of HHE increased PAIN threshold compared with control group in writhing and till flick tests (p<0. 001). Also the effect of administration of 400 mg/kg HHE was moreanalgesic that of morphine alone (p<0. 001). Diabetic group had low threshold to PAIN compared to control group. Conclusion: HHE has antinociceptive and anti-diabetic effects. We suggest the analgesic effects of HHE may be due to opioid system and also it effect on prostaglandins synthesis.

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APA: Copy

Moharerizadeh, Tayebeh, & Mirazi, Nasere. (2018). ANTINOCICEPTIVE EFFECT OF HERACLEUM PERSICUM LEAF HYDROETHANOLIC EXTRACT IN DIABETIC MALE MICE. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 39(5 ), 57-64. SID. https://sid.ir/paper/47119/en

Vancouver: Copy

Moharerizadeh Tayebeh, Mirazi Nasere. ANTINOCICEPTIVE EFFECT OF HERACLEUM PERSICUM LEAF HYDROETHANOLIC EXTRACT IN DIABETIC MALE MICE. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;39(5 ):57-64. Available from: https://sid.ir/paper/47119/en

IEEE: Copy

Tayebeh Moharerizadeh, and Nasere Mirazi, “ANTINOCICEPTIVE EFFECT OF HERACLEUM PERSICUM LEAF HYDROETHANOLIC EXTRACT IN DIABETIC MALE MICE,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 39, no. 5 , pp. 57–64, 2018, [Online]. Available: https://sid.ir/paper/47119/en

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