THE EFFECTS OF EPIGALLOCATECHIN GALLATE ON HER-2 GENE EXPRESSION OF THE HUMANBREAST ADENOCARCINOMA CELLS LINE (SK-BR-3)

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MOKHTARI MARYAM; ROUHI LEILA; ZIA JAHROMI NOOSHA; HEJAZI SEYED HOSSEIN

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Paper Information

Journal: MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:40 | Issue:4 Page(s): 68-72

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Title

THE EFFECTS OF EPIGALLOCATECHIN GALLATE ON HER-2 GENE EXPRESSION OF THE HUMANBREAST ADENOCARCINOMA CELLS LINE (SK-BR-3)

Author(s)

MOKHTARI MARYAM | ROUHI LEILA | ZIA JAHROMI NOOSHA | HEJAZI SEYED HOSSEIN | Issue Writer Certificate

Keywords

EPIGALLOCATECHIN-3 GALLATEQ1

BREAST CANCERQ2

HER-2Q1

REAL TIME RT-PCRQ1

SKBR3Q1

Abstract

Background: One of the most well-known oncogenes in BREAST CANCER is HER2 (ERBB2 or EGFR2). Naturalpolyphenols are one of the most effective components for inhibiting cancers due to their high efficiency and fewerside effects. Investigators have shown that green tea and its main catechin EPIGALLOCATECHIN-3 GALLATE (EGCG) maydecrease the risk of cancer. In the current study, we investigated the effect of EGCG on HER-2 gene expression ofthe human breast adenocarcinoma cells line SK-BR-3. Methods: SKBR-3 human BREAST CANCER cells were pretreated with different concentrations of EGCG (200 and400 μ g/mL) for 48 and 72 h. mRNA expression of HER-2 was detected by real time reverse transcriptasepolymerase chain reaction (RT-PCR) analysis in the pretreated SKBR-3 cells. Results: EGCG treatment in 48 and 72 h caused a dose-dependent decrease in mRNA expression of HER-2significantly in group I and group II vs. control group (P<0. 05). Conclusion: EPIGALLOCATECHIN-3 GALLATE has cytotoxic effect on SKBR3 cells. Our findings suggest that EGCGmay be useful in treatment of BREAST CANCER.

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