EVALUATION OF THE EFFECTS OF SELEGILINE AND AMANTADINE ON MORPHINE INDUCED TOLERANCE AND DEPENDENCE IN MICE

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HABIBIASL B.; PARVIZPUR A.R.; HASANZADEH K.A.D.; MAHDIKHANI M.

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Journal: PHARMACEUTICAL SCIENCES Year:2006 | Volume:- | Issue:3 Page(s): 33-38

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Title

EVALUATION OF THE EFFECTS OF SELEGILINE AND AMANTADINE ON MORPHINE INDUCED TOLERANCE AND DEPENDENCE IN MICE

Author(s)

HABIBIASL B. | PARVIZPUR A.R. | HASANZADEH K.A.D. | MAHDIKHANI M. | Issue Writer Certificate

Keywords

MORPHINEQ2

SELEGILINEQ2

AMANTADINEQ2

TOLERANCEQ2

WITHDRAWALQ2

Abstract

Objectives: Several studies have indicated that co-administration of N-methyl-D-aspartate (NMDA) receptor antagonists could attenuate the development of MORPHINE induced TOLERANCE and dependence in mice. The aim of this study was to investigate the effects of SELEGILINE (MAO-B inhibitor and NMDA receptor inhibitor) and AMANTADINE (NMDA receptor antagonist and Dopaminergic system activator) or their co administration on TOLERANCE (to analgesic effect) and WITHDRAWAL syndrome in mice. Methods: In different groups of mice MORPHINE (50 mg/kg, ip) or MORPHINE (50 mg/kg, ip) + SELEGILINE (10, 20, 40 mg/kg, ip) or MORPHINE (50 mg/kg, ip) + AMANTADINE (20, 40, 80 mg/kg , ip) or MORPHINE (50 mg/kg, ip) + AMANTADINE (20 mg/kg, ip) + SELEGILINE (10 mg/kg, ip) was administrated once a day for four days. The drugs (selegiline or AMANTADINE) administered 30 minutes before daily administration of MORPHINE (50 mg/kg, ip). TOLERANCE was assessed by administration of MORPHINE (9 mg/kg, ip) and using hot plate test on fifth day. To investigate the WITHDRAWAL symptoms (jumping and standing on feet) in different groups MORPHINE (50 mg/kg, ip) injected for 4 days. In the forth day half hour after the last injection, different doses of SELEGILINE, AMANTADINE or their co-administration were injected and after 1.5 hour later naloxone (5 mg/kg, ip) was injected and immediatly the WITHDRAWAL symptoms were detected during 30 minutes. Results: The results showed that different doses of AMANTADINE, increased the TOLERANCE to analgesic effects of MORPHINE significantly (P<0.001), WITHDRAWAL syndroms in the doses of 40 & 80 decreased significantly (P<0.01). But SELEGILINE (10, 20, 40 mg/kg, ip) did not have a siginificant effect on the inhibition of TOLERANCE and WITHDRAWAL syndromes. Co administration of SELEGILINE and AMANTADINE didn’t decrease the TOLERANCE to MORPHINE in hot plate test significantly. Conclution: It is concluded that, Probably AMANTADINE in this study has a mechanism of activation of dopaminergic system in the administered doses. On the other hand SELEGILINE potentiated adrenergic system with these doses.

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APA: Copy

HABIBIASL, B., PARVIZPUR, A.R., HASANZADEH, K.A.D., & MAHDIKHANI, M.. (2006). EVALUATION OF THE EFFECTS OF SELEGILINE AND AMANTADINE ON MORPHINE INDUCED TOLERANCE AND DEPENDENCE IN MICE. PHARMACEUTICAL SCIENCES, -(3), 33-38. SID. https://sid.ir/paper/48526/en

Vancouver: Copy

HABIBIASL B., PARVIZPUR A.R., HASANZADEH K.A.D., MAHDIKHANI M.. EVALUATION OF THE EFFECTS OF SELEGILINE AND AMANTADINE ON MORPHINE INDUCED TOLERANCE AND DEPENDENCE IN MICE. PHARMACEUTICAL SCIENCES[Internet]. 2006;-(3):33-38. Available from: https://sid.ir/paper/48526/en

IEEE: Copy

B. HABIBIASL, A.R. PARVIZPUR, K.A.D. HASANZADEH, and M. MAHDIKHANI, “EVALUATION OF THE EFFECTS OF SELEGILINE AND AMANTADINE ON MORPHINE INDUCED TOLERANCE AND DEPENDENCE IN MICE,” PHARMACEUTICAL SCIENCES, vol. -, no. 3, pp. 33–38, 2006, [Online]. Available: https://sid.ir/paper/48526/en

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