MICROENCAPSULATION OF BENZOYL PEROXIDE BY SUSPENSION POLYMERIZATION IN LIQUID-LIQUID SYSTEM METHOD

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JELVEHGARI M.; NOKHOUDCHI A.; SIAHI M.R.; DASTMALCHI S.

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Journal: PHARMACEUTICAL SCIENCES Year:2005 | Volume:- | Issue:3 Page(s): 53-63

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Title

MICROENCAPSULATION OF BENZOYL PEROXIDE BY SUSPENSION POLYMERIZATION IN LIQUID-LIQUID SYSTEM METHOD

Author(s)

JELVEHGARI M. | NOKHOUDCHI A. | SIAHI M.R. | DASTMALCHI S. | Issue Writer Certificate

Keywords

ANTI-ACNEQ2

BENZOYL PEROXIDEQ2

MICROSPONGESQ2

METHYL METHACRYLATEQ2

ETHYIEN GLYCOL DIMETHACRYLATEQ2

Abstract

Objective: BENZOYL PEROXIDE (BPO) is commonly used in topical formulations for the treatment of acne. Skin irritation is a common side effect, and it has been shown that controlled release of BPO from a delivery system to the skin could increase patient compliance and reduce the side effect while reducing percutaneous absorptioo. Method: In this study, MMA/EGDM copolymer was prepared by monomers METHYL METHACRYLATE and ethylene glycol dimethaaylate. After impregnating copolymer MMA/EGDM, MICROSPONGES were evaluated in respect to morphology, particle size, volume, pore size and molecular weight characteristics. Releases of drug from MICROSPONGES were investigated using Cell-Franz with dialysis membrane and drug release was determined by HPLC. Results: The results showed that the cumulative amount of release increased with an increase in the concentration of the active ingredient in the formula. The amount of drug released at the first hour was higher compared to its released amount at 2ndh. This could be due to the presence of non encapsulated BPO in these formulations. When the free BPO was released, the flux remained constant for the next 7 hrs. CONCLUSION: This flux represents the release of entrapped drug from MICROSPONGES. Released BPO in different dosage forms was respectively lotion < gel < cream. The topical microsponge delivery system can clearly maximize the amount of time that an active ingredient presents on the skin surface within the epidermis, therefore, into the body.

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APA: Copy

JELVEHGARI, M., NOKHOUDCHI, A., SIAHI, M.R., & DASTMALCHI, S.. (2005). MICROENCAPSULATION OF BENZOYL PEROXIDE BY SUSPENSION POLYMERIZATION IN LIQUID-LIQUID SYSTEM METHOD. PHARMACEUTICAL SCIENCES, -(3), 53-63. SID. https://sid.ir/paper/48553/en

Vancouver: Copy

JELVEHGARI M., NOKHOUDCHI A., SIAHI M.R., DASTMALCHI S.. MICROENCAPSULATION OF BENZOYL PEROXIDE BY SUSPENSION POLYMERIZATION IN LIQUID-LIQUID SYSTEM METHOD. PHARMACEUTICAL SCIENCES[Internet]. 2005;-(3):53-63. Available from: https://sid.ir/paper/48553/en

IEEE: Copy

M. JELVEHGARI, A. NOKHOUDCHI, M.R. SIAHI, and S. DASTMALCHI, “MICROENCAPSULATION OF BENZOYL PEROXIDE BY SUSPENSION POLYMERIZATION IN LIQUID-LIQUID SYSTEM METHOD,” PHARMACEUTICAL SCIENCES, vol. -, no. 3, pp. 53–63, 2005, [Online]. Available: https://sid.ir/paper/48553/en

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