PREPARATION AND PHARMACEUTICALS EVALUATION OF NICOTINE MUCCOADHESIVE TABLET FOR SMOKING CESSATION

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BAHRI NAJAFI R.; REZAEI Z.; SHABAB L.; PEYKANPOUR M.

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Journal: PHARMACEUTICAL SCIENCES Year:2012 | Volume:18 | Issue:2 Page(s): 93-102

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Title

PREPARATION AND PHARMACEUTICALS EVALUATION OF NICOTINE MUCCOADHESIVE TABLET FOR SMOKING CESSATION

Author(s)

BAHRI NAJAFI R. | REZAEI Z. | SHABAB L. | PEYKANPOUR M. | Issue Writer Certificate

Keywords

MUCOADHESIVE TABLETQ1

NICOTINEQ1

SMOKING CESSATIONQ1

Abstract

Objectives: NICOTINE replacement therapy (NRT) with gradual decreasing of NICOTINE is one of the SMOKING CESSATION methods. NICOTINE dosage forms on the market are including gum and skin patches. Muccoadhesive formulations are the novel drug delivery systems that are available in the form of tablets and films, and can be used for NRT. Muccoadhesive NICOTINE tablets (MNT) when placed in the upper gum, will release its NICOTINE content in a controlled manner. This will meet the need of the individual to the NICOTINE, such that the person can decrease his/her dependency on smoking.Methods: In the current study, the tablets were prepared using different conventional bioadhesive polymers such as HPMC50cps, NaCMC, and carbapol934 in singular or mixture form, magnesium hydroxide as the pH increasing agent, magnesium stearate as the lubricant, and lactose as the excipiente, of different products of NICOTINE hydrogen tartrate, which is more stable than the NICOTINE. Their pharmaceutics characteristics such as the degree of adhesion and the rate of drug release were evaluated.Results: Increasing of HPMC50cps in the formulations decrease speed release of NICOTINE. The carbapol in formulations beget slow releasing of NICOTINE. With increasing the percent of lactose, the rate of release in formulations was increased. Formulations which have HPMC 50cps has best adhesiveness. Formulations contains carbapol had not suitable adhesiveness.Formulations contains NaCMC were very fast release and had not suitable adhesiveness.Conclusion: The formulation contains mixture of HPMC50cps and Cp934 with suitable adhesiveness and minimum fluctuation in release, was the best formulation.

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APA: Copy

BAHRI NAJAFI, R., REZAEI, Z., SHABAB, L., & PEYKANPOUR, M.. (2012). PREPARATION AND PHARMACEUTICALS EVALUATION OF NICOTINE MUCCOADHESIVE TABLET FOR SMOKING CESSATION. PHARMACEUTICAL SCIENCES, 18(2), 93-102. SID. https://sid.ir/paper/48555/en

Vancouver: Copy

BAHRI NAJAFI R., REZAEI Z., SHABAB L., PEYKANPOUR M.. PREPARATION AND PHARMACEUTICALS EVALUATION OF NICOTINE MUCCOADHESIVE TABLET FOR SMOKING CESSATION. PHARMACEUTICAL SCIENCES[Internet]. 2012;18(2):93-102. Available from: https://sid.ir/paper/48555/en

IEEE: Copy

R. BAHRI NAJAFI, Z. REZAEI, L. SHABAB, and M. PEYKANPOUR, “PREPARATION AND PHARMACEUTICALS EVALUATION OF NICOTINE MUCCOADHESIVE TABLET FOR SMOKING CESSATION,” PHARMACEUTICAL SCIENCES, vol. 18, no. 2, pp. 93–102, 2012, [Online]. Available: https://sid.ir/paper/48555/en

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