STUDY OF THE HEPATOPROTECTIVE EFFECTS OF RUTIN ON ACETAMINOPHEN AND CARBON TETRACHLORIDE-INDUCED LIVER INJURY IN RATS

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ZIAEE A.; ZAMANSOLTANI F.; NASSIRI ASL M.; HADIGOL T.; GHASEMI M.

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Journal: PHARMACEUTICAL SCIENCES Year:2011 | Volume:17 | Issue:1 Page(s): 35-42

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Title

STUDY OF THE HEPATOPROTECTIVE EFFECTS OF RUTIN ON ACETAMINOPHEN AND CARBON TETRACHLORIDE-INDUCED LIVER INJURY IN RATS

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Keywords

RUTINQ1

ACETAMINOPHENQ2

CARBON TETRACHLORIDEQ1

LIVERQ1

HEPATOPROTECTIVEQ1

Abstract

Objectives: RUTIN (3, 3, 4, 5, 7-pentahydrohyflavone-3-rhamnoglucoside) is a nutrient, classified as a bioflavonoid. This study was carried out to determine the potential protective effect of RUTIN on ACETAMINOPHEN and CARBON TETRACHLORIDE (CCL4) induced LIVER injury.Methods: For ccl4, adult male Wistar rats were divided into 5 groups (n=7/group). Group 1 was treated by 1 mg/kg ccl4, twice a week. Group 2 received olive oil. Experimental groups (groups 3-5) received RUTIN at the doses of 10, 20 and 40 mg/kg respectively (i.p.) once a day plus ccl4. For the ACETAMINOPHEN study, another 5 groups (n=7/group) were assessed. Group 1 treated by 300 mg/kg ACETAMINOPHEN, twice a week. Group 2 received saline. Experimental groups (groups 3-5) received RUTIN at the doses of 10, 20 and 40 mg/kg respectively (i.p.) once a day plus ACETAMINOPHEN. After 8 weeks, LIVER functions were assessed by serum biochemistry of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). LIVER sections were stained with H&E for histopathological assessment.Results: Serum levels of ALT and AST were reduced significantly after 8 weeks treatment by RUTIN at the doses of 20 and 40 mg/kg (p<0.05). Reduction was more prominent at the dose of 20 mg/kg. Histopathological assessment was shown a reduction in LIVER damage at the doses of 20 and 40 mg/kg of RUTIN for ACETAMINOPHEN and 20 mg/kg for ccl4.Conclusion: Results suggest a potential HEPATOPROTECTIVE activity for RUTIN. Antioxidant and free radical scavenging properties, which has been shown by previous studies, may account for most of the protective effect of RUTIN.

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APA: Copy

ZIAEE, A., ZAMANSOLTANI, F., NASSIRI ASL, M., HADIGOL, T., & GHASEMI, M.. (2011). STUDY OF THE HEPATOPROTECTIVE EFFECTS OF RUTIN ON ACETAMINOPHEN AND CARBON TETRACHLORIDE-INDUCED LIVER INJURY IN RATS. PHARMACEUTICAL SCIENCES, 17(1), 35-42. SID. https://sid.ir/paper/48566/en

Vancouver: Copy

ZIAEE A., ZAMANSOLTANI F., NASSIRI ASL M., HADIGOL T., GHASEMI M.. STUDY OF THE HEPATOPROTECTIVE EFFECTS OF RUTIN ON ACETAMINOPHEN AND CARBON TETRACHLORIDE-INDUCED LIVER INJURY IN RATS. PHARMACEUTICAL SCIENCES[Internet]. 2011;17(1):35-42. Available from: https://sid.ir/paper/48566/en

IEEE: Copy

A. ZIAEE, F. ZAMANSOLTANI, M. NASSIRI ASL, T. HADIGOL, and M. GHASEMI, “STUDY OF THE HEPATOPROTECTIVE EFFECTS OF RUTIN ON ACETAMINOPHEN AND CARBON TETRACHLORIDE-INDUCED LIVER INJURY IN RATS,” PHARMACEUTICAL SCIENCES, vol. 17, no. 1, pp. 35–42, 2011, [Online]. Available: https://sid.ir/paper/48566/en

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