CALCULATION OF DRUG SOLUBILITY IN HYDRO-ALCOHOLIC MIXTURES USING MOBILE ORDER THEORY

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JOUYBAN A.A.GH.; BARZEGAR JALALI M.; NOKHOUDCHI A.; JABBARIBAR F.; HANAEI J.

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Journal: PHARMACEUTICAL SCIENCES Year:2004 | Volume:- | Issue:1 Page(s): 107-116

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Title

CALCULATION OF DRUG SOLUBILITY IN HYDRO-ALCOHOLIC MIXTURES USING MOBILE ORDER THEORY

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Keywords

SOLUBILITYQ2

COSOLVENCYQ3

MOBILE ORDER THEORYQ3

HYDRO-ALCOHOLIC MIXTURESQ3

PREDICTIONQ3

Abstract

Theory of mobile order for explaining the SOLUBILITY phenomenon was reviewed and the equations for representation of SOLUBILITY data in mono-solvent and binary solvent systems were discussed. The accuracy of the mobile order (MO) was evaluated using eleven SOLUBILITY data sets in water-ethanol mixtures and was compared with that of the combined nearly ideal binary solvent / Redlich-Kister (CNIBS/R-K) equation. The mean and standard deviations of the models were 2.70 ±1.44 and 1.31 ± 0.19, respectively for MO and CNIBS/R-Kand the mean difference was statistically significant. This suggested that MO is not capable of calculating solute SOLUBILITY more accurate than models based on classical thermodynamics and further studies is required to establish MO accuracy.

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APA: Copy

JOUYBAN, A.A.GH., BARZEGAR JALALI, M., NOKHOUDCHI, A., JABBARIBAR, F., & HANAEI, J.. (2004). CALCULATION OF DRUG SOLUBILITY IN HYDRO-ALCOHOLIC MIXTURES USING MOBILE ORDER THEORY. PHARMACEUTICAL SCIENCES, -(1), 107-116. SID. https://sid.ir/paper/48579/en

Vancouver: Copy

JOUYBAN A.A.GH., BARZEGAR JALALI M., NOKHOUDCHI A., JABBARIBAR F., HANAEI J.. CALCULATION OF DRUG SOLUBILITY IN HYDRO-ALCOHOLIC MIXTURES USING MOBILE ORDER THEORY. PHARMACEUTICAL SCIENCES[Internet]. 2004;-(1):107-116. Available from: https://sid.ir/paper/48579/en

IEEE: Copy

A.A.GH. JOUYBAN, M. BARZEGAR JALALI, A. NOKHOUDCHI, F. JABBARIBAR, and J. HANAEI, “CALCULATION OF DRUG SOLUBILITY IN HYDRO-ALCOHOLIC MIXTURES USING MOBILE ORDER THEORY,” PHARMACEUTICAL SCIENCES, vol. -, no. 1, pp. 107–116, 2004, [Online]. Available: https://sid.ir/paper/48579/en

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