STUDY OF THE CORRELATION BETWEEN INTRINSIC DISSOLUTION RATE AND SOME PHYSICOCHEMICAL AND PHARMACOKINETIC PARAMETERS OF THE COMPOUNDS

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ZAKERI MILANI P.; BARZEGAR JALALI M.; VALIZADEH H.; AZIMI MANDANA; HALAJNEZHADI S.

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Journal: PHARMACEUTICAL SCIENCES Year:2008 | Volume:- | Issue:3 Page(s): 21-31

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Title

STUDY OF THE CORRELATION BETWEEN INTRINSIC DISSOLUTION RATE AND SOME PHYSICOCHEMICAL AND PHARMACOKINETIC PARAMETERS OF THE COMPOUNDS

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Keywords

INTRINSIC DISSOLUTION RATEQ2

SOLUBILITYQ2

PHARMACOKINETIC PARAMETERSQ2

Abstract

Objectives: This study was designed to investigate the correlation between INTRINSIC DISSOLUTION RATE (IDR) and some physicochemical and PHARMACOKINETIC PARAMETERS of the compounds.Methods: 100mg of pure drug was compressed to prepare disc with smooth surface. Dissolution test was performed in sink condition using USP apparatus II and modified Wood & Syarto method. The slope of amount dissolved per unit area versus time was calculated using MS-Excel. This slope represents corresponding INTRINSIC DISSOLUTION RATE. SOLUBILITY of the compounds in buffer solution was determined using analytical method.Results: The results indicated that there was a linear correlation between logarithm of SOLUBILITY and logarithm of IDR with a slope of 0.7289, R2=0.94 and P value =0.00 but there was no clear relation between IDR and lipophilicity and polar surface area.Conclusion: This investigation revealed that IDR may correlate more closely with in vivo drug dissolution dynamics than SOLUBILITY. This could be attributed to the fact that the IDR is a rate phenomenon but SOLUBILITY is equilibrium phenomenon.

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APA: Copy

ZAKERI MILANI, P., BARZEGAR JALALI, M., VALIZADEH, H., AZIMI, MANDANA, & HALAJNEZHADI, S.. (2008). STUDY OF THE CORRELATION BETWEEN INTRINSIC DISSOLUTION RATE AND SOME PHYSICOCHEMICAL AND PHARMACOKINETIC PARAMETERS OF THE COMPOUNDS. PHARMACEUTICAL SCIENCES, -(3), 21-31. SID. https://sid.ir/paper/48611/en

Vancouver: Copy

ZAKERI MILANI P., BARZEGAR JALALI M., VALIZADEH H., AZIMI MANDANA, HALAJNEZHADI S.. STUDY OF THE CORRELATION BETWEEN INTRINSIC DISSOLUTION RATE AND SOME PHYSICOCHEMICAL AND PHARMACOKINETIC PARAMETERS OF THE COMPOUNDS. PHARMACEUTICAL SCIENCES[Internet]. 2008;-(3):21-31. Available from: https://sid.ir/paper/48611/en

IEEE: Copy

P. ZAKERI MILANI, M. BARZEGAR JALALI, H. VALIZADEH, MANDANA AZIMI, and S. HALAJNEZHADI, “STUDY OF THE CORRELATION BETWEEN INTRINSIC DISSOLUTION RATE AND SOME PHYSICOCHEMICAL AND PHARMACOKINETIC PARAMETERS OF THE COMPOUNDS,” PHARMACEUTICAL SCIENCES, vol. -, no. 3, pp. 21–31, 2008, [Online]. Available: https://sid.ir/paper/48611/en

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