A NOVEL PHARMACOLOGICAL ROLE FOR MINOCYCLINE: ATTENUATING THE WITHDRAWAL SYNDROME OF MORPHINE IN RAT

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HABIBIASL B.; SADEGH AMIRI O.; CHARKHPOUR M.; HASANZADEH K.

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Journal: PHARMACEUTICAL SCIENCES Year:2009 | Volume:15 | Issue:1 Page(s): 67-74

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Title

A NOVEL PHARMACOLOGICAL ROLE FOR MINOCYCLINE: ATTENUATING THE WITHDRAWAL SYNDROME OF MORPHINE IN RAT

Author(s)

HABIBIASL B. | SADEGH AMIRI O. | CHARKHPOUR M. | HASANZADEH K. | Issue Writer Certificate

Keywords

MORPHINEQ2

MINOCYCLINEQ1

WITHDRAWAL SYNDROMEQ2

DEPENDENCYQ2

NITRIC OXIDEQ1

Abstract

Objective: The aim of this study was to evaluate the effect of MINOCYCLINE on MORPHINE WITHDRAWAL SYNDROME in male rat. Methods: male wistar rats (225 – 275 g) were selected (n=8) randomly and divided in to six groups: In order to evaluate the effect of MINOCYCLINE on MORPHINE WITHDRAWAL SYNDROME. MORPHINE was administered subcutaneously for nine days: Day 1: 5mg/kg/12h, Day 2,3: 10 mg/kg/12h, Day 4,5: 15 mg/kh/12h, Day 6,7: 20 mg/kg/12h, Day 8,9: 25 mg/kg/12h. On ninth day only the morning dose of MORPHINE and MINOCYCLINE were injected. MINOCYCLINE was injected just before the MORPHINE injection twice a day, on ninth day an hour after the last dose of MORPHINE, naloxone ( 4 mg/kg’ ip) injected and the withdrawal signs (Jumping, Rearing, Genital Grooming, Abdomen Writhing and Wet Dog Shake) were recorded for 60 minutes. Animals received saline (1 ml/kg/12h’ ip) or {saline (1ml/kg/12h, ip) + MORPHINE (10 mg/kg/12h, sc) } or {minocycline (10,20,40 mg/kg/12h’ip) + MORPHINE (10 mg/kg/12h’sc) }. Result: Results showed that MINOCYCLINE decreased WITHDRAWAL SYNDROME significantly (p<0.001). Conclusion: MINOCYCLINE decreased the WITHDRAWAL SYNDROME of MORPHINE and the possible mechanism is related to inhibition of NITRIC OXIDE / N – methyl D – aspartat pathway.

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APA: Copy

HABIBIASL, B., SADEGH AMIRI, O., CHARKHPOUR, M., & HASANZADEH, K.. (2009). A NOVEL PHARMACOLOGICAL ROLE FOR MINOCYCLINE: ATTENUATING THE WITHDRAWAL SYNDROME OF MORPHINE IN RAT. PHARMACEUTICAL SCIENCES, 15(1), 67-74. SID. https://sid.ir/paper/48674/en

Vancouver: Copy

HABIBIASL B., SADEGH AMIRI O., CHARKHPOUR M., HASANZADEH K.. A NOVEL PHARMACOLOGICAL ROLE FOR MINOCYCLINE: ATTENUATING THE WITHDRAWAL SYNDROME OF MORPHINE IN RAT. PHARMACEUTICAL SCIENCES[Internet]. 2009;15(1):67-74. Available from: https://sid.ir/paper/48674/en

IEEE: Copy

B. HABIBIASL, O. SADEGH AMIRI, M. CHARKHPOUR, and K. HASANZADEH, “A NOVEL PHARMACOLOGICAL ROLE FOR MINOCYCLINE: ATTENUATING THE WITHDRAWAL SYNDROME OF MORPHINE IN RAT,” PHARMACEUTICAL SCIENCES, vol. 15, no. 1, pp. 67–74, 2009, [Online]. Available: https://sid.ir/paper/48674/en

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