EFFECTS OF QUERCETIN AND KAEMPFEROL VERSUS ALLOPURINOL ON SERUM URIC ACID LEVELS, BIOMARKERS OF OXIDATIVE STRESS AND HEPATIC XANTHINE OXIDASE/XANTHINE DEHYDROGENASE ACTIVITY IN HYPERURICEMIC RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HEYDARI FATEMEH; KESHAVARZ SEYED ALI; RASHIDI MOHAMMAD REZA; MAHBOUB S.A.; ESHRAGHIAN M.R.; MOHAMMAD SHAHI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: PHARMACEUTICAL SCIENCES Year:2009 | Volume:14 | Issue:4 Page(s): 301-309

Download Full-Text

Persian Verion

View:

1,351

Download:

Cites:

Information Journal Paper

Title

EFFECTS OF QUERCETIN AND KAEMPFEROL VERSUS ALLOPURINOL ON SERUM URIC ACID LEVELS, BIOMARKERS OF OXIDATIVE STRESS AND HEPATIC XANTHINE OXIDASE/XANTHINE DEHYDROGENASE ACTIVITY IN HYPERURICEMIC RATS

Author(s)

Keywords

QUERCETINQ2

KAEMPFEROLQ2

HYPERURICEMIAQ2

XANTHINE OXIDASEQ2

OXIDATIVE STRESSQ1

Abstract

Objectives: The aim of this study was to investigate the effect of oral administration of QUERCETIN (5 mg/kg) and KAEMPFEROL (5 mg/kg) versus allopurinol (5 mg/kg) on serum uric acid levels, biomarkers of OXIDATIVE STRESS (total antioxidant capacity and malondialdehyde concentration) and liver XANTHINE OXIDASE/xanthine dehydrogenase activity in normal and hyperuricemic rats. Methods: A total of 48 male Wistar rats (body weights: 180-200 g) were randomly divided into eight equal groups including normal; normal+QUERCETIN (5 mg/kg); normal+kaempferol (5 mg/kg); normal+allopurinol (5 mg/kg); hyperuricemic; hyperuricemic+QUERCETIN (5 mg/kg); hyperuricemic+kaempferol (5 mg/kg); hyperuricemic +allopurinol (5 mg/kg) once a day for 14 days. Experimentally HYPERURICEMIA in rats was induced by intraperitoneal injection of potassium oxonate (250 mg/kg). Results: QUERCETIN and KAEMPFEROL treatments for 14 days significantly reduced the serum uric acid levels of hyperuricemic rats in a timedependent manner. All treatments significantly inhibited hepatic XANTHINE OXIDASE/xanthine dehydrogenase activity. QUERCETIN and KAEMPFEROL treatment led also to a significant improve in biomarkers of OXIDATIVE STRESS in hyperuricemic rats. Although the hypouricemic effect of allopurinol was much higher than that of QUERCETIN and KAEMPFEROL, it could not significantly change OXIDATIVE STRESS biomarkers. Conclusion: The results indicate that these polyphenols could be as possible alternative for allopurinol, and/or as therapeutic supplements to minimize the side effects of allopurinol in treating HYPERURICEMIA and OXIDATIVE STRESS diseases.

Cites

No record.

References

No record.

Cite

APA: Copy

HEYDARI, FATEMEH, KESHAVARZ, SEYED ALI, RASHIDI, MOHAMMAD REZA, MAHBOUB, S.A., ESHRAGHIAN, M.R., & MOHAMMAD SHAHI, M.. (2009). EFFECTS OF QUERCETIN AND KAEMPFEROL VERSUS ALLOPURINOL ON SERUM URIC ACID LEVELS, BIOMARKERS OF OXIDATIVE STRESS AND HEPATIC XANTHINE OXIDASE/XANTHINE DEHYDROGENASE ACTIVITY IN HYPERURICEMIC RATS. PHARMACEUTICAL SCIENCES, 14(4), 301-309. SID. https://sid.ir/paper/48685/en

Vancouver: Copy

HEYDARI FATEMEH, KESHAVARZ SEYED ALI, RASHIDI MOHAMMAD REZA, MAHBOUB S.A., ESHRAGHIAN M.R., MOHAMMAD SHAHI M.. EFFECTS OF QUERCETIN AND KAEMPFEROL VERSUS ALLOPURINOL ON SERUM URIC ACID LEVELS, BIOMARKERS OF OXIDATIVE STRESS AND HEPATIC XANTHINE OXIDASE/XANTHINE DEHYDROGENASE ACTIVITY IN HYPERURICEMIC RATS. PHARMACEUTICAL SCIENCES[Internet]. 2009;14(4):301-309. Available from: https://sid.ir/paper/48685/en

IEEE: Copy

FATEMEH HEYDARI, SEYED ALI KESHAVARZ, MOHAMMAD REZA RASHIDI, S.A. MAHBOUB, M.R. ESHRAGHIAN, and M. MOHAMMAD SHAHI, “EFFECTS OF QUERCETIN AND KAEMPFEROL VERSUS ALLOPURINOL ON SERUM URIC ACID LEVELS, BIOMARKERS OF OXIDATIVE STRESS AND HEPATIC XANTHINE OXIDASE/XANTHINE DEHYDROGENASE ACTIVITY IN HYPERURICEMIC RATS,” PHARMACEUTICAL SCIENCES, vol. 14, no. 4, pp. 301–309, 2009, [Online]. Available: https://sid.ir/paper/48685/en

Related Journal Papers