EFFECT OF PEG MOLECULAR WEIGHT ON THE PHYSICOCHEMICAL PROPERTIES OF PIROXICAM SOLID DISPERSIONS PREPARED BY MELTING METHOD

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VALIZADEH H.; MOHAMMADI GH.; ADIBKIA KH.; ZAKERI MILANI P.; NOKHOUDCHI A.

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Journal: PHARMACEUTICAL SCIENCES Year:2005 | Volume:- | Issue:2 Page(s): 33-39

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Title

EFFECT OF PEG MOLECULAR WEIGHT ON THE PHYSICOCHEMICAL PROPERTIES OF PIROXICAM SOLID DISPERSIONS PREPARED BY MELTING METHOD

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Keywords

PIROXICAMQ2

SOLID DISPERSIONQ2

MELTINGMETHODQ2

PEGQ3

X-RAY DIFFRACTIONQ2

FT-IR SPECTROSCOPYQ2

DISSOLUTIONQ2

Abstract

OBJECTIVES: Proxicam is a poorely soluble, high, lypermeable drug and the rate of its oral absorption is often controlled by the DISSOLUTION rate in the gastrointestinal. In this study we tried to improve the DISSOLUTION rate of a poorly water soluble drug, PIROXICAM, by SOLID DISPERSION systems using PEG2000, PEG4000, PEG6000 and PEG20000 as hydrophilic carriers. The goal was to investigate the effect of PEG molecular weight of carrier on the DISSOLUTION properties of PIROXICAM. METHODS: The SOLID DISPERSIONs were prepared by melting method. The evaluation of the dispersions properties was performed using solubility measurements, DISSOLUTION studies, FT-IR SPECTROSCOPY and powder X-ray diffractometery (PXRD).RESULTS: Solubility studies revealed a marked increase in the solubility of PIROXICAM with an increase in PEG molecular weight as well as concentration. This may arise from the modification of polarity of the medium, hence solubilizing effect of carriers. An increased DISSOLUTION rate of PIROXICAM at pH 1.2 and 7.2 was observed when the drug was dispersed in these carriers. The DISSOLUTION rate of PIROXICAM was markedly increased from SOLID DISPERSION of PEG2000, PEG4000, PEG6000, PEG20000 but DISSOLUTION rate was decreased as molecular weight or concentration of PEG increased, which may be attributed to the increased viscosity around the solid particles. Data from the X-RAY DIFFRACTION and FT-IR SPECTROSCOPY showed that PIROXICAM crystallinity was decreased in the SOLID DISPERSIONs. CONCLUSION: DISSOLUTION byhavior and hence absorption rate PIROXICAM can be considerably enhanced by SOLID DISPERSION technique.

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APA: Copy

VALIZADEH, H., MOHAMMADI, GH., ADIBKIA, KH., ZAKERI MILANI, P., & NOKHOUDCHI, A.. (2005). EFFECT OF PEG MOLECULAR WEIGHT ON THE PHYSICOCHEMICAL PROPERTIES OF PIROXICAM SOLID DISPERSIONS PREPARED BY MELTING METHOD. PHARMACEUTICAL SCIENCES, -(2), 33-39. SID. https://sid.ir/paper/48712/en

Vancouver: Copy

VALIZADEH H., MOHAMMADI GH., ADIBKIA KH., ZAKERI MILANI P., NOKHOUDCHI A.. EFFECT OF PEG MOLECULAR WEIGHT ON THE PHYSICOCHEMICAL PROPERTIES OF PIROXICAM SOLID DISPERSIONS PREPARED BY MELTING METHOD. PHARMACEUTICAL SCIENCES[Internet]. 2005;-(2):33-39. Available from: https://sid.ir/paper/48712/en

IEEE: Copy

H. VALIZADEH, GH. MOHAMMADI, KH. ADIBKIA, P. ZAKERI MILANI, and A. NOKHOUDCHI, “EFFECT OF PEG MOLECULAR WEIGHT ON THE PHYSICOCHEMICAL PROPERTIES OF PIROXICAM SOLID DISPERSIONS PREPARED BY MELTING METHOD,” PHARMACEUTICAL SCIENCES, vol. -, no. 2, pp. 33–39, 2005, [Online]. Available: https://sid.ir/paper/48712/en

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