THE EFFECTS OF SURFACTANTS ON DISSOLUTION RATE OF LORAZEPAM FROM SOLID DISPERSION SYSTEMS

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SHOKRI J.; HANAEI J.; BARZEGAR JALALI M.; NASER ZADEH M.

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Journal: PHARMACEUTICAL SCIENCES Year:2005 | Volume:- | Issue:2 Page(s): 55-64

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Title

THE EFFECTS OF SURFACTANTS ON DISSOLUTION RATE OF LORAZEPAM FROM SOLID DISPERSION SYSTEMS

Author(s)

SHOKRI J. | HANAEI J. | BARZEGAR JALALI M. | NASER ZADEH M. | Issue Writer Certificate

Keywords

LORAZEPAMQ2

SOLID DISPERSIONSQ3

DISSOLUTION RATE ENHANCEMENTQ2

SURFACTANTQ3

Abstract

OBJECTIVES: LORAZEPAM is a practically insoluble drug which its oral absorption is limited by the dissolution rate, therefore, increasing LORAZEPAM dissolution rate may increase its bioavailability. SOLID DISPERSIONS with, hydrophilic carriers are the most effective techniques for improving dissolution rate of poorly water soluble drugs. Hydrophilic surface active agents are a group of compounds which can act as suitable carriers for SOLID DISPERSIONS of poorly water-soluble drugs. METHODS: In this study, SOLID DISPERSIONS of LORAZEPAM and three types of SURFACTANTs (SLS, CTAB and Myrj 52 as anionic, cationic and nonionic SURFACTANTs respectively) were prepared with different drug- carrier ratios (1: 0.1, 1:0.25, 1;0.5. 1:1 1:2 and 1:5). SOLID DISPERSIONS were prepared using solvent evaporation method and 75% hydroalcoholic solution was used as solvent. In-vitro dissolution rates of the SOLID DISPERSIONS were measured using dissolution rate apparatus (USP II) and compared with pure drug, treated drug and physical mixtures with the same drug- carrier ratios. FT-IR and XRD spectra were taken from samples for determining of any drug- carrier interaction and crystalline changes during co-evaporation process respectively. RESULTS: The results showed a significantly higher dissolution rate of SOLID DISPERSIONS in comparison with pure drug, treated drug and physical mixtures with the same drug- carrier ratios as SOLID DISPERSIONS. 1:0.5, 1:1 and 1:5 drug-carrier ratios were determined as the best ratios for LORAZEPAM- SLS, LORAZEPAM- CTAB and LORAZEPAM-Myrj52 SOLID DISPERSIONS respectively. FT-IR and XRD did not show any drug- carrier interaction and significant crystalline changes in drug during the processes respectively. CONCLUSION: solid dispersion techniques are very effective methods for enhancing dissolution rates of poorly water soluble drugs, and SURFACTANTs can be suitable carriers for them in SOLID DISPERSIONS.

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References

THE EFFECT OF VARIOUS SURFACTANTS ON THE SKIN STRUCTURE

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APA: Copy

SHOKRI, J., HANAEI, J., BARZEGAR JALALI, M., & NASER ZADEH, M.. (2005). THE EFFECTS OF SURFACTANTS ON DISSOLUTION RATE OF LORAZEPAM FROM SOLID DISPERSION SYSTEMS. PHARMACEUTICAL SCIENCES, -(2), 55-64. SID. https://sid.ir/paper/48714/en

Vancouver: Copy

SHOKRI J., HANAEI J., BARZEGAR JALALI M., NASER ZADEH M.. THE EFFECTS OF SURFACTANTS ON DISSOLUTION RATE OF LORAZEPAM FROM SOLID DISPERSION SYSTEMS. PHARMACEUTICAL SCIENCES[Internet]. 2005;-(2):55-64. Available from: https://sid.ir/paper/48714/en

IEEE: Copy

J. SHOKRI, J. HANAEI, M. BARZEGAR JALALI, and M. NASER ZADEH, “THE EFFECTS OF SURFACTANTS ON DISSOLUTION RATE OF LORAZEPAM FROM SOLID DISPERSION SYSTEMS,” PHARMACEUTICAL SCIENCES, vol. -, no. 2, pp. 55–64, 2005, [Online]. Available: https://sid.ir/paper/48714/en

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