EFFECTS OF SAFFRON EXTRACT ON SPERM PARAMETERS IN RATS WITH EXPERIMENTALLY INDUCED VARICOCELE

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AMIDI F.; EBRAHIMI S.; ABBASI M.; YAZDANI M.; GHASEMI S.

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Journal: Journal of Inflammatory Diseases Year:2015 | Volume:18 | Issue:5 (76) Page(s): 4-11

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Title

EFFECTS OF SAFFRON EXTRACT ON SPERM PARAMETERS IN RATS WITH EXPERIMENTALLY INDUCED VARICOCELE

Author(s)

Keywords

VARICOCELEQ3

SPERMATOZOAQ2

SPERM COUNTQ2

SPERM MOTILITYQ2

FERTILITYQ2

Abstract

Background: VARICOCELE is the most common cause of infertility in men. Increased release of free oxygen radicals is one of the most important mechanisms of damage in the pathophysiology of VARICOCELE.Objective: The aim of this study was to determine the effects of saffron extract treatment on sperm parameters (sperm count, motility and morphology) in rats with experimentally induced VARICOCELE.Methods: In this experimental study, 24 male Wistar rats were randomly divided into four groups: VARICOCELE without treatment, sham, control, VARICOCELE with treatment. VARICOCELE was induced in both VARICOCELE groups. Saffron ethanolic extract (50 mg/kg) was daily administered intraperitoneally in the VARICOCELE group with treatment for eight weeks. After eight weeks, the sperm parameters were studied in all groups. Data were analyzed using one way ANOVA.Findings: All sperm parameters in the VARICOCELE groups were significantly reduced in comparison to the control group. The sperm parameters were significantly improved by saffron ethanolic extract.Conclusion: With regards to the results, crocin and safranal in saffron extract which probably eliminate free radicals can be effective in treatment of infertility caused by VARICOCELE.

Cites

INCREASING VIABILITY, NUMBERS, AND MOTILITY OF SPERM IN MEN WITH NORMAL SPERMATOGENESIS EXPOSED TO SAFFRON EXTRACT AFTER FREEZING- THAWING PROCESS

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APA: Copy

AMIDI, F., EBRAHIMI, S., ABBASI, M., YAZDANI, M., & GHASEMI, S.. (2015). EFFECTS OF SAFFRON EXTRACT ON SPERM PARAMETERS IN RATS WITH EXPERIMENTALLY INDUCED VARICOCELE. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), 18(5 (76)), 4-11. SID. https://sid.ir/paper/49042/en

Vancouver: Copy

AMIDI F., EBRAHIMI S., ABBASI M., YAZDANI M., GHASEMI S.. EFFECTS OF SAFFRON EXTRACT ON SPERM PARAMETERS IN RATS WITH EXPERIMENTALLY INDUCED VARICOCELE. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2015;18(5 (76)):4-11. Available from: https://sid.ir/paper/49042/en

IEEE: Copy

F. AMIDI, S. EBRAHIMI, M. ABBASI, M. YAZDANI, and S. GHASEMI, “EFFECTS OF SAFFRON EXTRACT ON SPERM PARAMETERS IN RATS WITH EXPERIMENTALLY INDUCED VARICOCELE,” JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), vol. 18, no. 5 (76), pp. 4–11, 2015, [Online]. Available: https://sid.ir/paper/49042/en

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