THE COMPARISON BETWEEN EFFECT OF CHEMORADIATION WITH WEEKLY CISPLATIN WITH OR WITHOUT CELECOXIB IN TREATMENT OF NASOPHARYNGEAL CARCINOMA:A PHASE III CLINICAL TRIAL

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOHAMMADIANPANAH M.; RAZMJOU GHALAEI S.; KHADEMI B.; SHAFIEIZADEH AMIN; OMIDVARI SH.; MOSALAEI A.; AHMADLOU N.; ANSARI MANSOUR

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF OTORHINOLARYNGOLOGY Year:2009 | Volume:21 | Issue:2 (56) Page(s): 55-62

Download Full-Text

Persian Verion

View:

1,734

Download:

Cites:

Information Journal Paper

Title

THE COMPARISON BETWEEN EFFECT OF CHEMORADIATION WITH WEEKLY CISPLATIN WITH OR WITHOUT CELECOXIB IN TREATMENT OF NASOPHARYNGEAL CARCINOMA:A PHASE III CLINICAL TRIAL

Author(s)

Keywords

CELECOXIBQ1

CHEMOTHERAPYQ1

NASOPHARYNGEAL CARCINOMAQ1

RADIOTHERAPYQ1

RESPONSE RATEQ1

Abstract

Introduction: Concurrent cisplatin-based chemoradiation is currently considered the treatment of choice for locoregional NASOPHARYNGEAL CARCINOMA. CELECOXIB is a selective cyclooxygenase-2 (COX-2) inhibitor which can potentially enhance the effect of RADIOTHERAPY. The aim of this study was to determine the efficacy and safety of CELECOXIB in NASOPHARYNGEAL CARCINOMA.Materials and Methods: Patients with newly diagnosed locoregional NASOPHARYNGEAL CARCINOMA were included in this clinical trial study. The patients were assigned to receive 7 weeks concurrent chemoradiation with weekly cisplatin and either CELECOXIB 100 mg twice daily or placebo. After completion of chemoradiation, all patients received combined CHEMOTHERAPY with cisplatin plus 5-Fu every 3 weeks for 3 cycles. Clinical RESPONSE RATEs and treatment-related toxicity were the primary and secondary end-point of the study.Results: Total of 50 eligible patients with the median age of 43 years was enrolled in the trial. Overall (complete and partial) clinical RESPONSE RATE was 100% in both groups. Complete and partial clinical RESPONSE RATEs were 64% and 36% in study group and 44% and 56% in control group respectively (P>0.25). There was no difference in terms of treatment-related toxicity rates between two groups.Conclusions: This clinical trial showed that addition of CELECOXIB 100 mg twice daily to concurrent chemoradiation does not increase the RESPONSE RATEs and treatment-related toxicities in patients with locoregional NASOPHARYNGEAL CARCINOMA.

Cites

No record.

References

No record.

Cite

APA: Copy

MOHAMMADIANPANAH, M., RAZMJOU GHALAEI, S., KHADEMI, B., SHAFIEIZADEH, AMIN, OMIDVARI, SH., MOSALAEI, A., AHMADLOU, N., & ANSARI, MANSOUR. (2009). THE COMPARISON BETWEEN EFFECT OF CHEMORADIATION WITH WEEKLY CISPLATIN WITH OR WITHOUT CELECOXIB IN TREATMENT OF NASOPHARYNGEAL CARCINOMA:A PHASE III CLINICAL TRIAL. IRANIAN JOURNAL OF OTORHINOLARYNGOLOGY, 21(2 (56)), 55-62. SID. https://sid.ir/paper/49400/en

Vancouver: Copy

MOHAMMADIANPANAH M., RAZMJOU GHALAEI S., KHADEMI B., SHAFIEIZADEH AMIN, OMIDVARI SH., MOSALAEI A., AHMADLOU N., ANSARI MANSOUR. THE COMPARISON BETWEEN EFFECT OF CHEMORADIATION WITH WEEKLY CISPLATIN WITH OR WITHOUT CELECOXIB IN TREATMENT OF NASOPHARYNGEAL CARCINOMA:A PHASE III CLINICAL TRIAL. IRANIAN JOURNAL OF OTORHINOLARYNGOLOGY[Internet]. 2009;21(2 (56)):55-62. Available from: https://sid.ir/paper/49400/en

IEEE: Copy

M. MOHAMMADIANPANAH, S. RAZMJOU GHALAEI, B. KHADEMI, AMIN SHAFIEIZADEH, SH. OMIDVARI, A. MOSALAEI, N. AHMADLOU, and MANSOUR ANSARI, “THE COMPARISON BETWEEN EFFECT OF CHEMORADIATION WITH WEEKLY CISPLATIN WITH OR WITHOUT CELECOXIB IN TREATMENT OF NASOPHARYNGEAL CARCINOMA:A PHASE III CLINICAL TRIAL,” IRANIAN JOURNAL OF OTORHINOLARYNGOLOGY, vol. 21, no. 2 (56), pp. 55–62, 2009, [Online]. Available: https://sid.ir/paper/49400/en

Related Journal Papers