EVALUATION OF THE ASSOCIATION BETWEEN INTERLEUKIN-6 GENE POLYMORPHISM (IL6 174 G>C) WITH THE COMPLICATIONS AFTER THE CORONARY ARTERY BYPASS GRAFT SURGERY IN IRANIAN PATIENTS

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GHAEMI YASAMAN; SABZGHABAEE ALI MOHAMMAD; MIRMOHAMMAD SADEGHI MOHSEN; HASHEMI MOHAMMAD; SOLEIMANI BAHRAM; MIRMOHAMMAD SADEGHI HAMID

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Journal: Journal of Isfahan Medical School Year:2011 | Volume:29 | Issue:160 Page(s): 1486-1495

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Title

EVALUATION OF THE ASSOCIATION BETWEEN INTERLEUKIN-6 GENE POLYMORPHISM (IL6 174 G>C) WITH THE COMPLICATIONS AFTER THE CORONARY ARTERY BYPASS GRAFT SURGERY IN IRANIAN PATIENTS

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Keywords

POLYMORPHISMQ2

IL6 GENEQ2

POST OPERATIVE COMPLICATIONSQ2

CABGQ3

Abstract

Background: Interleukin-6 (IL6) gene POLYMORPHISM is an important inflammatory cytokine. It may play a major role in complications observed after CABG surgery. Therefore, the present study was designed to study the relationship between IL6 174G>C gene POLYMORPHISM and complications after CABG. The aim of this study was to investigate any probable relationship between IL6 174 G>C POLYMORPHISM and complications observed after CABG surgery.Methods: In this case-control study, whole blood samples were obtained from all patients hospitalized for CABG surgery in Sina Hospital, Isfahan. Subject were divided into two groups of patients with (POC) or without (NPOC) complications. Information such as age, sex, degree of hemorrhage after the surgery, time spent in the intensive care unit (ICU), ventilation time, and inotropic support after the surgery was collected. Statistical analysis of the obtained data was performed using t-test and chi-square test.Findings: We did not find a correlation between IL6 GENE POLYMORPHISM and complications after CABG surgery (P=0.126). However, a significant difference was observed. This difference for GG was P=0.05 and for GC was P=0.035 between two groups.Conclusion: GG genotype may play a role for the inflammation and complications after CABG. Further studies with larger number of patients are recommended.

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APA: Copy

GHAEMI, YASAMAN, SABZGHABAEE, ALI MOHAMMAD, MIRMOHAMMAD SADEGHI, MOHSEN, HASHEMI, MOHAMMAD, SOLEIMANI, BAHRAM, & MIRMOHAMMAD SADEGHI, HAMID. (2011). EVALUATION OF THE ASSOCIATION BETWEEN INTERLEUKIN-6 GENE POLYMORPHISM (IL6 174 G>C) WITH THE COMPLICATIONS AFTER THE CORONARY ARTERY BYPASS GRAFT SURGERY IN IRANIAN PATIENTS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 29(160), 1486-1495. SID. https://sid.ir/paper/49721/en

Vancouver: Copy

GHAEMI YASAMAN, SABZGHABAEE ALI MOHAMMAD, MIRMOHAMMAD SADEGHI MOHSEN, HASHEMI MOHAMMAD, SOLEIMANI BAHRAM, MIRMOHAMMAD SADEGHI HAMID. EVALUATION OF THE ASSOCIATION BETWEEN INTERLEUKIN-6 GENE POLYMORPHISM (IL6 174 G>C) WITH THE COMPLICATIONS AFTER THE CORONARY ARTERY BYPASS GRAFT SURGERY IN IRANIAN PATIENTS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2011;29(160):1486-1495. Available from: https://sid.ir/paper/49721/en

IEEE: Copy

YASAMAN GHAEMI, ALI MOHAMMAD SABZGHABAEE, MOHSEN MIRMOHAMMAD SADEGHI, MOHAMMAD HASHEMI, BAHRAM SOLEIMANI, and HAMID MIRMOHAMMAD SADEGHI, “EVALUATION OF THE ASSOCIATION BETWEEN INTERLEUKIN-6 GENE POLYMORPHISM (IL6 174 G>C) WITH THE COMPLICATIONS AFTER THE CORONARY ARTERY BYPASS GRAFT SURGERY IN IRANIAN PATIENTS,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 29, no. 160, pp. 1486–1495, 2011, [Online]. Available: https://sid.ir/paper/49721/en

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