EFFECT OF BROMOCRIPTINE ON GLYCEMIC CONTROL OF OBESE TYPE II DIABETIC PATIENTS

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AMIN ALROAYA A.; RAMEZANI MAJID; AMINI MASOUD

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2004 | Volume:21 | Issue:71 Page(s): 24-27

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Title

EFFECT OF BROMOCRIPTINE ON GLYCEMIC CONTROL OF OBESE TYPE II DIABETIC PATIENTS

Author(s)

AMIN ALROAYA A. | RAMEZANI MAJID | AMINI MASOUD | Issue Writer Certificate

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Abstract

Introduction: Bromocriptine has been tried to control plasma glucose level of type 2 diabetic patients with controversial reported results, in recent years. In present study, the effect of this drug on glycemic control of obese type 2 diabetic patients has been evaluated. Methods: In a double blind placebo - controlled clinical trial, 60 obese types 2, diabetic patients were evaluated. They had uncontrolled diabetes on fixed doses of OHA within 3 months before enrolling the research. Patients randomly were divided into two groups, one group were administered "bromocriptine 2.5 mg/d and another, "Placebo" OHAs oral hypoglycemic agents in both groups continued without changing in dosage. Fasting plasma glucose (FBS) level, glycosilated hemoglobine (HbA1) were measured and body mass index (BMI) was calculated before and after each months of treament for 3 successive months in each group. The mentioned parameters were compared with their baselines and also during this period of time. Data were reported as mean±SE. Statistical analysis was done with paired and independent t-test P-Values less than 0.05 were statistically considered as significant. Results: FBS level decreased within 3 months in bromocriptine treated group. (191± 6.21mg/dl VS 161± 5.56 mg/dl, P<0.001). Its decrease in placebo group was nonsignificant (193±7.5mg/dl VS 187±7.7mg/dl, NS). HbA1 concentration decreased in case group during this period of time (9.8%±0.2 VS 9.36% ±02, P<0.002). While it increased in placebo treated group, although it was not statistically significant (10.2%± 0.2 VS 11.1±0.4, NS). BMI did not change in both groups. Discussion: Bromocriptine administration decreased FBS and HbA1 in obese type 2 diabetic patients. It may be helpful as adjuvant therapy and also as monotherapy in these patients with only mildy elevated blood glucose levels.

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APA: Copy

AMIN ALROAYA, A., RAMEZANI, MAJID, & AMINI, MASOUD. (2004). EFFECT OF BROMOCRIPTINE ON GLYCEMIC CONTROL OF OBESE TYPE II DIABETIC PATIENTS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 21(71), 24-27. SID. https://sid.ir/paper/49943/en

Vancouver: Copy

AMIN ALROAYA A., RAMEZANI MAJID, AMINI MASOUD. EFFECT OF BROMOCRIPTINE ON GLYCEMIC CONTROL OF OBESE TYPE II DIABETIC PATIENTS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2004;21(71):24-27. Available from: https://sid.ir/paper/49943/en

IEEE: Copy

A. AMIN ALROAYA, MAJID RAMEZANI, and MASOUD AMINI, “EFFECT OF BROMOCRIPTINE ON GLYCEMIC CONTROL OF OBESE TYPE II DIABETIC PATIENTS,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 21, no. 71, pp. 24–27, 2004, [Online]. Available: https://sid.ir/paper/49943/en

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