INVESTIGATION OF ASSOCIATION BETWEEN GENETIC DIVERSITIES IN YQ11.223 REGION WITH MEN INFERTILITY IN ISFAHAN POPULATION

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MOTOVALI BASHI MAJID; HOJATI ZOHREH; REZAEI ZAHRA; HEMMATI SIMIN

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Journal: Journal of Isfahan Medical School Year:2011 | Volume:29 | Issue:142 Page(s): 707-713

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Title

INVESTIGATION OF ASSOCIATION BETWEEN GENETIC DIVERSITIES IN YQ11.223 REGION WITH MEN INFERTILITY IN ISFAHAN POPULATION

Author(s)

MOTOVALI BASHI MAJID | HOJATI ZOHREH | REZAEI ZAHRA | HEMMATI SIMIN | Issue Writer Certificate

Keywords

MEN INFERTILITYQ2

DELETION IN AZOOSPERMIAQ2

AZOOSPERMIA FACTORQ2

Abstract

Background: Infertility is one of the important human problems. One of the main genetic factors of infertility is the deletions in the chromosome Y‚ which is reported in 10-15% of men with severe azoospermia and oligospermia. Three regions in AZOOSPERMIA FACTOR (AZFa), (AZFb) and (AZFc) are specified as the spermatogenetic regions. In this study we investigated the effect of changes in Yq11.223 (DAZ) region in chromosome Y on infertility.Methods: In this study the blood samples of 100 infertile men who referred to the Infertility Center of Isfahan and 100 healthy people, as the control group were taken. The genomic DNA was extracted from blood samples. The analyses were performed by applying the polymerase chain reaction (PCR) technique in AZF region of Yq11.223.Findings: In this study 70 azoospermia and 30 oligospermia patients were investigated. The deletions in AZF region of Yq11.223 were recognized in 7 azoospermia patients but there were not detected in oligospermia patients and the control group. It was also observed that the intensity of bands were changed comparing between azoospermia patients.Conclusion: Deletion frequency in the region of Yq11.223 was observed in 7 of 100 (7%) infertile Oligospermia and Azoospermia men. Our results confirm the effect of DAZ in the man’s infertility.

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APA: Copy

MOTOVALI BASHI, MAJID, HOJATI, ZOHREH, REZAEI, ZAHRA, & HEMMATI, SIMIN. (2011). INVESTIGATION OF ASSOCIATION BETWEEN GENETIC DIVERSITIES IN YQ11.223 REGION WITH MEN INFERTILITY IN ISFAHAN POPULATION. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 29(142), 707-713. SID. https://sid.ir/paper/49959/en

Vancouver: Copy

MOTOVALI BASHI MAJID, HOJATI ZOHREH, REZAEI ZAHRA, HEMMATI SIMIN. INVESTIGATION OF ASSOCIATION BETWEEN GENETIC DIVERSITIES IN YQ11.223 REGION WITH MEN INFERTILITY IN ISFAHAN POPULATION. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2011;29(142):707-713. Available from: https://sid.ir/paper/49959/en

IEEE: Copy

MAJID MOTOVALI BASHI, ZOHREH HOJATI, ZAHRA REZAEI, and SIMIN HEMMATI, “INVESTIGATION OF ASSOCIATION BETWEEN GENETIC DIVERSITIES IN YQ11.223 REGION WITH MEN INFERTILITY IN ISFAHAN POPULATION,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 29, no. 142, pp. 707–713, 2011, [Online]. Available: https://sid.ir/paper/49959/en

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