THE EFFECT AND MECHANISM OF ACTION OF INSULIN-LIKE GROWTH FACTOR-1 AND INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-3 IN HUMAN BREAST CANCER; A SYSTEMATIC REVIEW

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KHODADADI EMAD; ATAEI NEGAR; MOFID MOHAMMAD REZA

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Journal: Journal of Isfahan Medical School Year:2013 | Volume:31 | Issue:254 Page(s): 1560-1567

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Title

THE EFFECT AND MECHANISM OF ACTION OF INSULIN-LIKE GROWTH FACTOR-1 AND INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-3 IN HUMAN BREAST CANCER; A SYSTEMATIC REVIEW

Author(s)

KHODADADI EMAD | ATAEI NEGAR | MOFID MOHAMMAD REZA | Issue Writer Certificate

Keywords

BREAST CANCERQ2

IGFBP3Q2

IGFQ2

1Q2

Abstract

Background: BREAST CANCER is the most common malignancy in women. Many factors such as estrogens, nutrition, etc. play role in the incidence of this cancer. Insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) are the factors recently considered as components of insulin-like growth factor (IGF) system.Methods: Studies in this field from 1987 to 2012 by using the databases of NCBI (http://www.ncbi.nlm.nih.gov/) were analyzed and reviewedFindings: 1181 article had examined the effect of IGF-1 in BREAST CANCER. 46 showed a direct association with BREAST CANCER. 92 articles were studied relation of IGF-1 and IGFBP-3 with BREAST CANCER, 9 of them were review articles. Of these, 30 articles were selected as the main references.Conclusion: Studies have shown that IGF-1 gene expression increases in BREAST CANCER. IGF-1 effects in growth, proliferation and tumor genesis is mediated by IGF-1R. IGFBP3/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank"> IGFBP3 inhibit IGF-1 effects by preventing its binding to a surface receptor (IGF-1R) and interferes with IGF-1 mitoses action. Also, in a mechanism independent on IGF, IGFBP-3 binds to specific membrane proteins and induces apoptosis and inhibits cell growth.

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APA: Copy

KHODADADI, EMAD, ATAEI, NEGAR, & MOFID, MOHAMMAD REZA. (2013). THE EFFECT AND MECHANISM OF ACTION OF INSULIN-LIKE GROWTH FACTOR-1 AND INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-3 IN HUMAN BREAST CANCER; A SYSTEMATIC REVIEW. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 31(254), 1560-1567. SID. https://sid.ir/paper/50033/en

Vancouver: Copy

KHODADADI EMAD, ATAEI NEGAR, MOFID MOHAMMAD REZA. THE EFFECT AND MECHANISM OF ACTION OF INSULIN-LIKE GROWTH FACTOR-1 AND INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-3 IN HUMAN BREAST CANCER; A SYSTEMATIC REVIEW. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2013;31(254):1560-1567. Available from: https://sid.ir/paper/50033/en

IEEE: Copy

EMAD KHODADADI, NEGAR ATAEI, and MOHAMMAD REZA MOFID, “THE EFFECT AND MECHANISM OF ACTION OF INSULIN-LIKE GROWTH FACTOR-1 AND INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-3 IN HUMAN BREAST CANCER; A SYSTEMATIC REVIEW,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 31, no. 254, pp. 1560–1567, 2013, [Online]. Available: https://sid.ir/paper/50033/en

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