EPSTEIN-BARR VIRUS IN BREAST CARCINOMA: A STUDY ON AN IRANIAN POPULATION

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MOKHTARI MOJGAN; NAJI FAEGHEH SADAT; NAJAFI MOHAMMAD AMIN; BAHREINI ISFAHANI MONA

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2016 | Volume:34 | Issue:388 Page(s): 724-729

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Title

EPSTEIN-BARR VIRUS IN BREAST CARCINOMA: A STUDY ON AN IRANIAN POPULATION

Author(s)

MOKHTARI MOJGAN | NAJI FAEGHEH SADAT | NAJAFI MOHAMMAD AMIN | BAHREINI ISFAHANI MONA | Issue Writer Certificate

Keywords

INVASIVE DUCTAL CARCINOMAQ1

BREASTQ1

EPSTEIN–BARR VIRUS (EBV)Q1

EPSTEIN–BARR NUCLEAR ANTIGEN (EBNA-1)Q1

POLYMERASE CHAIN REACTION (PCR)Q1

Abstract

Background: INVASIVE DUCTAL CARCINOMA (IDC) is the most frequent type of BREAST carcinoma. Epstein-Barr virus is the most suspicious virus for the viral etiology of BREAST cancer. The aim of this study was to determine the expression of EBV nuclear antigen-1 (EBNA-1) in IDC.Methods: 40 Iranian women with INVASIVE DUCTAL CARCINOMA of BREAST were enrolled in this study. Tumors were assessed for the expression of EBNA1 antigen by PCR technique. Demographics of patients as well as characteristics of tumors including size, grade, and axillary lymph node status were collected and compared between EBNA1 positive and EBNA1 negative tumors.Findings: The mean age of patients was 48.7 year. EBNA-1 PCR assay was positive in 11 patients (27.5%). The mean diameter of tumors was 4.43 cm. Axillary lymph nodes were involved in 22 patients. Tumors were grade I, II, and III in 5, 19, and 16 patients, respectively. EBNA-1 positive tumors were significantly larger than EBNA-1 negative tumors (5.5±2.6 vs.4.0±2.4; P=0.049).Conclusion: According to the results of this study, EBV might have a role in the pathogenesis of BREAST cancer.

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APA: Copy

MOKHTARI, MOJGAN, NAJI, FAEGHEH SADAT, NAJAFI, MOHAMMAD AMIN, & BAHREINI ISFAHANI, MONA. (2016). EPSTEIN-BARR VIRUS IN BREAST CARCINOMA: A STUDY ON AN IRANIAN POPULATION. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 34(388), 724-729. SID. https://sid.ir/paper/50143/en

Vancouver: Copy

MOKHTARI MOJGAN, NAJI FAEGHEH SADAT, NAJAFI MOHAMMAD AMIN, BAHREINI ISFAHANI MONA. EPSTEIN-BARR VIRUS IN BREAST CARCINOMA: A STUDY ON AN IRANIAN POPULATION. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2016;34(388):724-729. Available from: https://sid.ir/paper/50143/en

IEEE: Copy

MOJGAN MOKHTARI, FAEGHEH SADAT NAJI, MOHAMMAD AMIN NAJAFI, and MONA BAHREINI ISFAHANI, “EPSTEIN-BARR VIRUS IN BREAST CARCINOMA: A STUDY ON AN IRANIAN POPULATION,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 34, no. 388, pp. 724–729, 2016, [Online]. Available: https://sid.ir/paper/50143/en

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