THE EFFECT OF THE BLOCKAGE OF THE RECEPTORS OF GLUTAMATE N-METHYL-D-ASPARTATE (NMDA) IN PREFRONTAL CORTEX ON MORPHINE TENDENCY IN MALE RAT

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JAVADI SAMAD; ALAEI HOJJATALLAH; HOSSEINI SEYED EBRAHIM; RADAHMADI MARYAM

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Journal: Journal of Isfahan Medical School Year:2016 | Volume:34 | Issue:400 Page(s): 1114-1120

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Title

THE EFFECT OF THE BLOCKAGE OF THE RECEPTORS OF GLUTAMATE N-METHYL-D-ASPARTATE (NMDA) IN PREFRONTAL CORTEX ON MORPHINE TENDENCY IN MALE RAT

Author(s)

JAVADI SAMAD | ALAEI HOJJATALLAH | HOSSEINI SEYED EBRAHIM | RADAHMADI MARYAM | Issue Writer Certificate

Keywords

MORPHINEQ2

NQ1

METHYLQ1

DQ1

ASPARTATE (NMDA)Q2

ANTAGONIST RECEPTORQ3

CONDITIONED PLACE PREFERENCEQ2

ADDICTIONQ2

GLUTAMATEQ2

PREFRONTAL CORTEXQ2

Abstract

Background: ADDICTION is a brain Disorder associated with Neurobiologic changes. Medial PREFRONTAL CORTEX (mPFC) plays an important role in learning, memory, reward system and ADDICTION processes. Present study investigated the effect of 2-amino-5-phosphopentanoic acid (AP5), GLUTAMATE receptor antagonist, on MORPHINE tendency.Methods: We used 27 groups (n=6) of male Wistar rats; 7 groups were used for Determining the effective and ineffective Doses of MORPHINE and 20 experimental groups also were used for studying the effect of various Doses of AP5 on MORPHINE tendency in acquisition and expression phases of CONDITIONED PLACE PREFERENCE (CPP) paradigm; then, CPP index was calculatedFindings: Doses of 2.5, 5, 7.5 and 10 mg/kg of MORPHINE significantly increased CPP index in MORPHINE groups compared to saline group (P<0.050, P<0.001, P<0.010 and P<0.001, respectively) but, in Doses of 0.5 and 1 mg/kg of MORPHINE, the changes were Not significant. Microinjection of Different Doses of AP5 into the PREFRONTAL CORTEX with injection of the effective Dose of MORPHINE significantly reduced the acquisition and the expression phases of CPP in test groups compared to the sham group, while the ineffective Dose of MORPHINE reduced the expression phase of CPP paradigm (P<0.001) and Did Not have significant effect on the acquisition phase of CPP.Conclusion: It seems that microinjection of AP5 into the PREFRONTAL CORTEX reduces CPP index and consequently MORPHINE tendency; these may be Due to the impairment of learning and Dysfunction of reward-related memory in response to MORPHINE.

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APA: Copy

JAVADI, SAMAD, ALAEI, HOJJATALLAH, HOSSEINI, SEYED EBRAHIM, & RADAHMADI, MARYAM. (2016). THE EFFECT OF THE BLOCKAGE OF THE RECEPTORS OF GLUTAMATE N-METHYL-D-ASPARTATE (NMDA) IN PREFRONTAL CORTEX ON MORPHINE TENDENCY IN MALE RAT. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 34(400), 1114-1120. SID. https://sid.ir/paper/50163/en

Vancouver: Copy

JAVADI SAMAD, ALAEI HOJJATALLAH, HOSSEINI SEYED EBRAHIM, RADAHMADI MARYAM. THE EFFECT OF THE BLOCKAGE OF THE RECEPTORS OF GLUTAMATE N-METHYL-D-ASPARTATE (NMDA) IN PREFRONTAL CORTEX ON MORPHINE TENDENCY IN MALE RAT. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2016;34(400):1114-1120. Available from: https://sid.ir/paper/50163/en

IEEE: Copy

SAMAD JAVADI, HOJJATALLAH ALAEI, SEYED EBRAHIM HOSSEINI, and MARYAM RADAHMADI, “THE EFFECT OF THE BLOCKAGE OF THE RECEPTORS OF GLUTAMATE N-METHYL-D-ASPARTATE (NMDA) IN PREFRONTAL CORTEX ON MORPHINE TENDENCY IN MALE RAT,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 34, no. 400, pp. 1114–1120, 2016, [Online]. Available: https://sid.ir/paper/50163/en

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