THE EXPRESSION OF TOX3 GENE IN PATIENTS WITH ESOPHAGEAL CANCER

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AHMADI BALOOTAKI SORAYA; EMADI BAYGY MODJTABA; ROUHI LEILA; SHAYESTEH ALI AKBAR

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Paper Information

Journal: Journal of Isfahan Medical School Year:2016 | Volume:34 | Issue:395 Page(s): 971-977

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Title

THE EXPRESSION OF TOX3 GENE IN PATIENTS WITH ESOPHAGEAL CANCER

Author(s)

AHMADI BALOOTAKI SORAYA | EMADI BAYGY MODJTABA | ROUHI LEILA | SHAYESTEH ALI AKBAR | Issue Writer Certificate

Keywords

TOX3 GENEQ1

REALQ1

TIME POLYMERASE CHAIN REACTIONQ1

SYBR GREENQ3

ESOPHAGEAL CANCERQ3

Abstract

Background: ESOPHAGEAL CANCER is the sixth cause of cancer mortality worldwide. While it is the sixth prevalent cancer in Iran, its incidence has been decreasing during the past 3 decades. Belonging to the HMG-box protein family, TOX3 (TOX high-mobility group box family member 3) gene is located on 16q12 chromosome. This study aimed to compare the expression of TOX3 GENE in cancerous and non-cancerous tissue of esophagus.Methods: In this case-control study 40 formalin-fixed, paraffin-embedded (FFPE) samples of cases of esophageal Squamous cell carcinoma (SCC) and healthy tisuue were assessed. Samples were collected from patients referred to Imam Khomeini Hospital, Ahvaz, Iran, during 2005 to 2010. Total RNA was extracted and complementary DNA (cDNA) was synthesied. The relative gene expression was determined using quantitative REAL-time reverse transcriptase polymerase chain reaction (qRT-PCR) and quantified using 2-ΔΔCT method.Findings: The expression of TOX3 GENE was lower in tumor tissues compared to normal tissues. However, it was not statistically significant (P>0.1).Conclusion: Our study revealed that the expression of TOX3 is lower in squamous ESOPHAGEAL CANCER. Consequently, by considering all the data about the expression of TOX3 GENE from various resources, it could be suggested that the TOX3 GENE might act as a tumor suppressor in esophageal squamous cell carcinoma. Therefore, further studies should be done to elucidate the exact mechanism of action of the gene as a tumor suppressor in Squamous cell carcinoma.

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References

A COMPARATIVE STUDY OF IMPACT OF PERSONAL FACTORS ON SURVIVAL OF PATIENTS WITH ESOPHAGEAL CANCER USING WEIBULL OR LOG-NORMAL CURE MODELS

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APA: Copy

AHMADI BALOOTAKI, SORAYA, EMADI BAYGY, MODJTABA, ROUHI, LEILA, & SHAYESTEH, ALI AKBAR. (2016). THE EXPRESSION OF TOX3 GENE IN PATIENTS WITH ESOPHAGEAL CANCER. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 34(395), 971-977. SID. https://sid.ir/paper/50178/en

Vancouver: Copy

AHMADI BALOOTAKI SORAYA, EMADI BAYGY MODJTABA, ROUHI LEILA, SHAYESTEH ALI AKBAR. THE EXPRESSION OF TOX3 GENE IN PATIENTS WITH ESOPHAGEAL CANCER. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2016;34(395):971-977. Available from: https://sid.ir/paper/50178/en

IEEE: Copy

SORAYA AHMADI BALOOTAKI, MODJTABA EMADI BAYGY, LEILA ROUHI, and ALI AKBAR SHAYESTEH, “THE EXPRESSION OF TOX3 GENE IN PATIENTS WITH ESOPHAGEAL CANCER,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 34, no. 395, pp. 971–977, 2016, [Online]. Available: https://sid.ir/paper/50178/en

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