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Information Journal Paper

Title

CLINICAL SIGNS, HOSPITALIZATION DURATION AND OUTCOME OF TRAMADOL INTOXICATION

Pages

  1187-1193

Keywords

Abstract

 Background: Regarding increasing TRAMADOL TOXICITY in recent years due to usage of TRAMADOL as a drug for suppression of withdrawal symptoms and high availability of this drug, we did a survey on the frequency of TRAMADOL intoxication symptoms, duration of admission, therapeutic measurements, TRAMADOL dosage, and prognosis of the patients.Methods: We conducted a cross sectional study, in which information of every patient with TRAMADOL TOXICITY admitted in Noor hospital ward of toxicology (Isfahan, Iran) were gathered and analyzed.Finding: From 184 cases, 141 (76.6%) were men. The mean age of the patients was 24±7 years. Forty percent of patient had positive history of substance abuse. Eighty four cases (45.6%) were with co-ingestion. Thirty four percent of patients had chronic ingestion of TRAMADOL. The most common chief complaint was central nervous system (CNS) depression (57%) followed by seizure (25%), bradypnea (18%), tachycardia (25%), and hypertension (7%). Active charcol (89%), gastric lavage (81%), naloxane (25%), anti convulsants (11%), and intubation and ventilation (5%) were done as therapeutic acts. The most common complication in patients was aspiration pneumonia. Two (1.1%) patients died. There were significant relationships between TRAMADOL dose and seizure (P=0.036), ataxia (P=0.002), and outcome (P<0.001).Conclusion: TRAMADOL OVERDOSE frequently cause CNS depression, respiratory depression, tachycardia, hypertension, and seizure; these symptoms could be from both effects of TRAMADOL either on mu receptor or inhibition of monoamine reuptake.

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  • Cite

    APA: Copy

    EISADI MOOD, NASTARAN, SABZGHABAEE, ALI MOHAMMAD, SAFDARI, AZADEH, & YARAGHI, AHMAD. (2011). CLINICAL SIGNS, HOSPITALIZATION DURATION AND OUTCOME OF TRAMADOL INTOXICATION. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 28(117), 1187-1193. SID. https://sid.ir/paper/50351/en

    Vancouver: Copy

    EISADI MOOD NASTARAN, SABZGHABAEE ALI MOHAMMAD, SAFDARI AZADEH, YARAGHI AHMAD. CLINICAL SIGNS, HOSPITALIZATION DURATION AND OUTCOME OF TRAMADOL INTOXICATION. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2011;28(117):1187-1193. Available from: https://sid.ir/paper/50351/en

    IEEE: Copy

    NASTARAN EISADI MOOD, ALI MOHAMMAD SABZGHABAEE, AZADEH SAFDARI, and AHMAD YARAGHI, “CLINICAL SIGNS, HOSPITALIZATION DURATION AND OUTCOME OF TRAMADOL INTOXICATION,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 28, no. 117, pp. 1187–1193, 2011, [Online]. Available: https://sid.ir/paper/50351/en

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