TRINUCLEOTIDE REPEAT POLYMORPHISM IN TRANSFORMING GROWTH FACTOR BETA RECEPTOR TYPE 1 GENE AND RISK OF BREAST CANCER

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KAMALI ELAHE; TAVASSOLI MANOOCHEHR; HEMATTI SIMIN; KARIMI PADIDEH; KHERADMAND PARISA

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2013 | Volume:31 | Issue:250 Page(s): 1369-1377

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Title

TRINUCLEOTIDE REPEAT POLYMORPHISM IN TRANSFORMING GROWTH FACTOR BETA RECEPTOR TYPE 1 GENE AND RISK OF BREAST CANCER

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Keywords

POLYMORPHISMQ2

BREAST CANCERQ2

TRANSFORMING GROWTH FACTOR BETA RECEPTOR TYPE 1Q2

GCG REPEATQ2

Abstract

Background: TRANSFORMING GROWTH FACTOR BETA RECEPTOR TYPE 1 (TGFBR1) is a serine–threonine protein kinase which mediates the growth-inhibitory signals of TGFB1 through a complex with TGFBR2. Numerous epidemiological studies have evaluated the association of TGFBR1 POLYMORPHISMs and the risk of cancer. The purpose of this study was to investigate the tri-nucleotide POLYMORPHISM (GCG) in exon 1 of TGFBR1 gene and its association with risk of BREAST CANCER in women.Methods: This study was conducted on 200 women with BREAST CANCER and 200 healthy women in Isfahan, Iran. After DNA extraction from peripheral blood samples, desired sequence was amplified by polymerase chain reaction (PCR). Finally, GCG REPEAT POLYMORPHISM was determined by polyacrylamide gel electrophoresis and direct sequencing.Findings: The TGFBR1 gene allele distribution in studied women varied between 6 and 9. The most common allele in both controls and cases was (GCG)9. The frequencies of (GCG)6 allele or homozygote of (GCG)6 in patients were significantly lower than controls.Conclusion: Contrary to previous reports, our findings demonstrate that women who carry two alleles of (GCG) 6 of TGFBR1 gene are at lower risk of developing BREAST CANCER. Our results suggest a protective role of this allele against BREAST CANCER.

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APA: Copy

KAMALI, ELAHE, TAVASSOLI, MANOOCHEHR, HEMATTI, SIMIN, KARIMI, PADIDEH, & KHERADMAND, PARISA. (2013). TRINUCLEOTIDE REPEAT POLYMORPHISM IN TRANSFORMING GROWTH FACTOR BETA RECEPTOR TYPE 1 GENE AND RISK OF BREAST CANCER. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 31(250), 1369-1377. SID. https://sid.ir/paper/50644/en

Vancouver: Copy

KAMALI ELAHE, TAVASSOLI MANOOCHEHR, HEMATTI SIMIN, KARIMI PADIDEH, KHERADMAND PARISA. TRINUCLEOTIDE REPEAT POLYMORPHISM IN TRANSFORMING GROWTH FACTOR BETA RECEPTOR TYPE 1 GENE AND RISK OF BREAST CANCER. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2013;31(250):1369-1377. Available from: https://sid.ir/paper/50644/en

IEEE: Copy

ELAHE KAMALI, MANOOCHEHR TAVASSOLI, SIMIN HEMATTI, PADIDEH KARIMI, and PARISA KHERADMAND, “TRINUCLEOTIDE REPEAT POLYMORPHISM IN TRANSFORMING GROWTH FACTOR BETA RECEPTOR TYPE 1 GENE AND RISK OF BREAST CANCER,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 31, no. 250, pp. 1369–1377, 2013, [Online]. Available: https://sid.ir/paper/50644/en

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